The Journal of Experimental Medicine
VeriKine-HS Human IFN-Beta
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Journal of Experimental Medicine, Vol 164, 944-949, Copyright © 1986 by Rockefeller University Press

ARTICLES

Induction of the c-myc protooncogene after antigen binding to hapten- specific B cells

EC Snow, JD Fetherston and S Zimmer

The stimulation of hapten-specific B cell populations with the thymus- dependent antigen, TNP-KLH, was found to induce elevated levels of c- myc mRNA by 2 h. A similar treatment with carrier protein alone did not elevate c-myc mRNA above the level seen in the nonstimulated, resting B cells. These results indicate that antigen binding to the sIg receptor, in the absence of Th cell involvement, directly signals the antigen- binding cell and implicates the active participation of sIg during the process of antigen-mediated B cell activation.
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