Journal of Experimental Medicine, Vol 164, 932-937, Copyright © 1986 by Rockefeller University Press

ARTICLES

Cytotoxic T lymphocytes against disease-associated determinant(s) in ankylosing spondylitis

AF Geczy, LE McGuigan, JS Sullivan and JP Edmonds

Cytotoxic T lymphocytes, induced by stimulating the PBMC of an HLA-B27+ normal individual (B27+, AS-) with the PBMC of an HLA-identical sibling suffering from ankylosing spondylitis (AS) (B27+, AS+), specifically lyse B27+, AS+ PBMC but not PBMC from HLA-27+ or B27-, AS- normal controls, or from HLA-B27- AS patients (B27-,AS+). CTL of similar specificity can also be raised by immunizing in vitro B27+,AS- cells with autologous cells modified by cross-reactive bacterial antigens. These results suggest that CTL can recognize certain bacterial antigens in association with HLA-B27 and that this interaction may lead to an inflammatory episode during the initial stages of the disease.
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This article has been cited by other articles:

• Ringrose, J H (1999). HLA-B27 associated spondyloarthropathy, an autoimmune disease based on crossreactivity between bacteria and HLA-B27?. Ann Rheum Dis 58: 598-610 [Abstract] [Full Text]  
• Yu, D. T.Y., Choo, S. Y., Schaack, T. (1989). Molecular Mimicry in HLA-B27-Related Arthritis. ANN INTERN MED 111: 581-591 [Abstract]  

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