A new HLA-linked T cell membrane molecule, related to the beta chain of the clonotypic receptor, is associated with T3

doi:10.1084/jem.164.2.458

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A new HLA-linked T cell membrane molecule, related to the beta chain of the clonotypic receptor, is associated with T3

Y Bushkin, DN Posnett, B Pernis and CY Wang

The 38 kD molecule is noncovalently associated with beta 2 microglobulin (beta 2m)-free HLA heavy chain-like molecule, and thus forms a second heterodimer distinct from the clonotypic alpha/beta T cell receptor expressed by the same clone of leukemia cells. This second heterodimer (38 kD/HLA) is variably expressed and appears to be associated with the T3 molecule. We suggest, therefore, that it has a functional role in T cell activation.
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