Human CD3+ T lymphocytes that express neither CD4 nor CD8 antigens

doi:10.1084/jem.164.1.339

This Article

	Full Text (PDF, 727K)
	Alert me when this article is cited

Services

	Email this article
	Similar articles in this journal
	Similar articles in PubMed
	Alert me to new content in the JEM
	Download to citation manager

Citing Articles

	Citing Articles via HighWire
	Citing Articles via CrossRef
	Citing Articles via Google Scholar

Google Scholar

	Articles by Lanier, L. L.
	Articles by Phillips, J. H.
	Search for Related Content

PubMed

	PubMed Citation
	Articles by Lanier, L. L.
	Articles by Phillips, J. H.


Social Bookmarking

	What's this?

ARTICLES

Human CD3+ T lymphocytes that express neither CD4 nor CD8 antigens

LL Lanier, JJ Ruitenberg and JH Phillips

CD3+ T lymphocytes expressing neither CD4 nor CD8 antigens exist in normal human peripheral blood in low frequency (approximately 3% of lymphocytes). The CD3+,4-,8- phenotype was stably maintained after in vitro culture in IL-2. Culture of CD3+,4-,8- cells in only rIL-2 generated cytotoxic T cells that lysed NK-sensitive and NK-insensitive tumor cell targets without MHC restriction. These experiments clearly show that phenotypically and functionally competent T cells expressing neither CD4 nor CD8 are present in normal peripheral blood.
Add to CiteULike CiteULike Add to Complore Complore Add to Connotea Connotea Add to Del.icio.us Del.icio.us Add to Digg Digg Facebook Add to Reddit Reddit Add to Technorati Technorati Twitter What's this?

This article has been cited by other articles:

Fehniger, T. A., Caligiuri, M. A. (2001). Interleukin 15: biology and relevance to human disease. Blood 97: 14-32 [Full Text]
Nam, K.-H., Akari, H., Terao, K., Shibata, H., Kawamura, S., Yoshikawa, Y. (2000). Peripheral blood extrathymic CD4+CD8+ T cells with high cytotoxic activity are from the same lineage as CD4+CD8- T cells in cynomolgus monkeys. Int Immunol 12: 1095-1103 [Abstract] [Full Text]
Lim, M. S., Straus, S. E., Dale, J. K., Fleisher, T. A., Stetler-Stevenson, M., Strober, W., Sneller, M. C., Puck, J. M., Lenardo, M. J., Elenitoba-Johnson, K. S. J., Lin, A. Y., Raffeld, M., Jaffe, E. S. (1998). Pathological Findings in Human Autoimmune Lymphoproliferative Syndrome. Am. J. Pathol. 153: 1541-1550 [Abstract] [Full Text]
Fredrikson, S., Ernerudh, J., Olsson, T., Forsberg, P., Link, H. (1989). Mononuclear Cell Types in Cerebrospinal Fluid and Blood of Patients With Multiple Sclerosis: Quantitation by Immunoenzyme Microassay With Panel of Monoclonal Antibodies. Arch Neurol 46: 372-375 [Abstract]