Administration of group A streptococcal cell walls to rats induces an interleukin 2 deficiency

doi:10.1084/jem.164.1.327

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Administration of group A streptococcal cell walls to rats induces an interleukin 2 deficiency

SC Ridge, JB Zabriskie, H Osawa, T Diamantstein, AL Oronsky and SS Kerwar

Intraperitoneal administration of group A streptococcal cell walls to Lewis rats induces a chronic arthritis, whereas the Fischer strain is resistant to the development of the lesion. Spleen cells from cell wall- treated rats (Lewis and Fischer) are deficient in the synthesis of IL- 2. Using an mAb directed against the rat IL-2-R, the present studies indicate that the expression of IL-2-R on spleens of cell wall-treated rats is normal. However, the addition of exogenous IL-2 to spleen cells cultured with Con A does not stimulate the mitogenic response.
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Richards, P. J., Williams, B. D., Williams, A. S. (2001). Suppression of chronic streptococcal cell wall-induced arthritis in Lewis rats by liposomal clodronate. Rheumatology (Oxford) 40: 978-987 [Abstract] [Full Text]