The Journal of Experimental Medicine
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Journal of Experimental Medicine, Vol 163, 1314-1318, Copyright © 1986 by Rockefeller University Press

ARTICLES

Gamma gene rearrangement and expression in autoreactive helper T cells

M Zauderer, A Iwamoto and TW Mak

gamma gene rearrangements similar to those described for cytotoxic T cell lines are found in L3T4+, autoreactive, or KLH-specific cloned helper T cell lines. High levels of gamma RNA transcripts were, in addition, detected in four out of five L3T4+, class II MHC-specific, autoreactive T cell clones, and in at least one of three KLH-specific, class II MHC-restricted clones. This contrasts with previously reported (9) expression of gamma RNA in only 1 of 11 antigen-specific helper T cell lines.
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