Purification and partial characterization of the nephritis strain- associated protein from Streptococcus pyogenes, group A

doi:10.1084/jem.163.3.697

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Purification and partial characterization of the nephritis strain- associated protein from Streptococcus pyogenes, group A

KH Johnston and JB Zabriskie

We report the isolation and purification of the nephritis strain- associated protein (NSAP) first described by Villareal et al. (8). Amino acid analysis, and determination of the first 21 amino-terminal amino acids indicated that this 46 kD protein is a streptokinase. Biochemical analysis confirmed that NSAP could act as a plasminogen activator; immunological investigations indicated that NSAP is antigenically different from streptokinase from group C streptococcus, and possibly represents a unique streptokinase. It is this uniqueness that may contribute to the role of NSAP in the pathogenesis of acute poststreptococcal glomerulonephritis.
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