Dendritic cells with antigen-presenting capability reside in airway epithelium, lung parenchyma, and visceral pleura

doi:10.1084/jem.163.2.436

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Dendritic cells with antigen-presenting capability reside in airway epithelium, lung parenchyma, and visceral pleura

K Sertl, T Takemura, E Tschachler, VJ Ferrans, MA Kaliner and EM Shevach

In this study, we identified a population of dendritic cells (DC) that exists throughout human and mouse pulmonary tissues, including the trachea, bronchi, alveoli, and visceral pleura. In human tissue, these DC were shown to be positive for HLA-DR and T200 antigens. In the mouse, the DC expressed not only Ia and the T200 antigen, but also Fc- IgG and C3bi receptors. Unlike alveolar macrophages, the DC were negative for nonspecific esterase staining and shared ultrastructural similarities with the DC described by Steinman (1), and with Langerhans' cells, even though they did not contain Birbeck granules. We were able to demonstrate that mouse pulmonary DC function in antigen presentation, as observed with the other DC. Thus, the respiratory tract contains DC that are capable of functioning in antigen presentation and that may be important in pulmonary immune responses.
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Demedts, I. K., Bracke, K. R., Van Pottelberge, G., Testelmans, D., Verleden, G. M., Vermassen, F. E., Joos, G. F., Brusselle, G. G. (2007). Accumulation of Dendritic Cells and Increased CCL20 Levels in the Airways of Patients with Chronic Obstructive Pulmonary Disease. Am. J. Respir. Crit. Care Med. 175: 998-1005 [Abstract] [Full Text]
Matthews, K. E., Karabeg, A., Roberts, J. M., Saeland, S., Dekan, G., Epstein, M. M., Ronchese, F. (2007). Long-Term Deposition of Inhaled Antigen in Lung Resident CD11b-CD11c+ Cells. Am. J. Respir. Cell Mol. Bio. 36: 435-441 [Abstract] [Full Text]
Beaty, S. R., Rose, C. E. Jr., Sung, S.-s. J. (2007). Diverse and Potent Chemokine Production by Lung CD11bhigh Dendritic Cells in Homeostasis and in Allergic Lung Inflammation. J. Immunol. 178: 1882-1895 [Abstract] [Full Text]
Masten, B. J., Olson, G. K., Tarleton, C. A., Rund, C., Schuyler, M., Mehran, R., Archibeque, T., Lipscomb, M. F. (2006). Characterization of Myeloid and Plasmacytoid Dendritic Cells in Human Lung. J. Immunol. 177: 7784-7793 [Abstract] [Full Text]
Demedts, I. K., Bracke, K. R., Maes, T., Joos, G. F., Brusselle, G. G. (2006). Different Roles for Human Lung Dendritic Cell Subsets in Pulmonary Immune Defense Mechanisms. Am. J. Respir. Cell Mol. Bio. 35: 387-393 [Abstract] [Full Text]
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Sung, S.-S. J., Fu, S. M., Rose, C. E. Jr., Gaskin, F., Ju, S.-T., Beaty, S. R. (2006). A Major Lung CD103 ({alpha}E)-beta7 Integrin-Positive Epithelial Dendritic Cell Population Expressing Langerin and Tight Junction Proteins. J. Immunol. 176: 2161-2172 [Abstract] [Full Text]
Vermaelen, K., Pauwels, R. (2005). Pulmonary Dendritic Cells. Am. J. Respir. Crit. Care Med. 172: 530-551 [Abstract] [Full Text]
Holt, P. G. (2005). Pulmonary Dendritic Cells in Local Immunity to Inert and Pathogenic Antigens in the Respiratory Tract. Proc Am Thorac Soc 2: 116-120 [Abstract] [Full Text]
Gagliardi, M. C., Teloni, R., Giannoni, F., Pardini, M., Sargentini, V., Brunori, L., Fattorini, L., Nisini, R. (2005). Mycobacterium bovis Bacillus Calmette-Guerin infects DC-SIGN- dendritic cell and causes the inhibition of IL-12 and the enhancement of IL-10 production. J. Leukoc. Biol. 78: 106-113 [Abstract] [Full Text]
Padilla, J., Daley, E., Chow, A., Robinson, K., Parthasarathi, K., McKenzie, A. N. J., Tschernig, T., Kurup, V. P., Donaldson, D. D., Grunig, G. (2005). IL-13 Regulates the Immune Response to Inhaled Antigens. J. Immunol. 174: 8097-8105 [Abstract] [Full Text]
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Marino, S., Pawar, S., Fuller, C. L., Reinhart, T. A., Flynn, J. L., Kirschner, D. E. (2004). Dendritic Cell Trafficking and Antigen Presentation in the Human Immune Response to Mycobacterium tuberculosis. J. Immunol. 173: 494-506 [Abstract] [Full Text]
Masten, B. J., Olson, G. K., Kusewitt, D. F., Lipscomb, M. F. (2004). Flt3 Ligand Preferentially Increases the Number of Functionally Active Myeloid Dendritic Cells in the Lungs of Mice. J. Immunol. 172: 4077-4083 [Abstract] [Full Text]
Bhatt, K., Hickman, S. P., Salgame, P. (2004). Cutting Edge: A New Approach to Modeling Early Lung Immunity in Murine Tuberculosis. J. Immunol. 172: 2748-2751 [Abstract] [Full Text]
Brimnes, M. K., Bonifaz, L., Steinman, R. M., Moran, T. M. (2003). Influenza Virus-induced Dendritic Cell Maturation Is Associated with the Induction of Strong T Cell Immunity to a Coadministered, Normally Nonimmunogenic Protein. JEM 198: 133-144 [Abstract] [Full Text]
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Bukreyev, A., Skiadopoulos, M. H., McAuliffe, J., Murphy, B. R., Collins, P. L., Schmidt, A. C. (2002). More antibody with less antigen: Can immunogenicity of attenuated live virus vaccines be improved?. Proc. Natl. Acad. Sci. USA 99: 16987-16991 [Abstract] [Full Text]
Giacomini, E., Iona, E., Ferroni, L., Miettinen, M., Fattorini, L., Orefici, G., Julkunen, I., Coccia, E. M. (2001). Infection of Human Macrophages and Dendritic Cells with Mycobacterium tuberculosis Induces a Differential Cytokine Gene Expression That Modulates T Cell Response. J. Immunol. 166: 7033-7041 [Abstract] [Full Text]
Leemans, J. C., Juffermans, N. P., Florquin, S., van Rooijen, N., Vervoordeldonk, M. J., Verbon, A., van Deventer, S. J. H., van der Poll, T. (2001). Depletion of Alveolar Macrophages Exerts Protective Effects in Pulmonary Tuberculosis in Mice. J. Immunol. 166: 4604-4611 [Abstract] [Full Text]
Gildea, L. A., Morris, R. E., Newman, S. L. (2001). Histoplasma capsulatum Yeasts Are Phagocytosed Via Very Late Antigen-5, Killed, and Processed for Antigen Presentation by Human Dendritic Cells. J. Immunol. 166: 1049-1056 [Abstract] [Full Text]
Mohagheghpour, N., van Vollenhoven, A., Goodman, J., Bermudez, L. E. (2000). Interaction of Mycobacterium avium with Human Monocyte-Derived Dendritic Cells. Infect. Immun. 68: 5824-5829 [Abstract] [Full Text]
Fortsch, D., Rollinghoff, M., Stenger, S. (2000). IL-10 Converts Human Dendritic Cells into Macrophage-Like Cells with Increased Antibacterial Activity Against Virulent Mycobacterium tuberculosis. J. Immunol. 165: 978-987 [Abstract] [Full Text]
Tazi, A., Soler, P., Hance, A. J (2000). Rare diseases bullet 9: Adult pulmonary Langerhans' cell histiocytosis. Thorax 55: 405-416 [Full Text]
Wang, J., Snider, D. P., Hewlett, B. R., Lukacs, N. W., Gauldie, J., Liang, H., Xing, Z. (2000). Transgenic expression of granulocyte-macrophage colony-stimulating factor induces the differentiation and activation of a novel dendritic cell population in the lung. Blood 95: 2337-2345 [Abstract] [Full Text]
Beck, S. E., Jones, L. A., Chesnut, K., Walsh, S. M., Reynolds, T. C., Carter, B. J., Askin, F. B., Flotte, T. R., Guggino, W. B. (1999). Repeated Delivery of Adeno-Associated Virus Vectors to the Rabbit Airway. J. Virol. 73: 9446-9455 [Abstract] [Full Text]
Lee, S.-C., Jaffar, Z. H., Wan, K.-S., Holgate, S. T., Roberts, K. (1999). Regulation of Pulmonary T Cell Responses to Inhaled Antigen: Role in Th1- and Th2-Mediated Inflammation. J. Immunol. 162: 6867-6879 [Abstract] [Full Text]
Childers, N. K., Tong, G., Mitchell, S., Kirk, K., Russell, M. W., Michalek, S. M. (1999). A Controlled Clinical Study of the Effect of Nasal Immunization with a Streptococcus mutans Antigen Alone or Incorporated into Liposomes on Induction of Immune Responses. Infect. Immun. 67: 618-623 [Abstract] [Full Text]
Masten, B. J., Lipscomb, M. F. (1999). Comparison of Lung Dendritic Cells and B Cells in Stimulating Naive Antigen-Specific T Cells. J. Immunol. 162: 1310-1317 [Abstract] [Full Text]
Gjomarkaj, M., Pace, E., Melis, M., Spatafora, M., Profita, M., Vignola, A. M., Bonsignore, G., Toews, G. B. (1999). Phenotypic and Functional Characterization of Normal Rat Pleural Macrophages in Comparison with Autologous Peritoneal and Alveolar Macrophages. Am. J. Respir. Cell Mol. Bio. 20: 135-142 [Abstract] [Full Text]
SPINA, D. (1998). Epithelium Smooth Muscle Regulation and Interactions. Am. J. Respir. Crit. Care Med. 158: S141-S145 [Abstract] [Full Text]
Mohagheghpour, N., Gammon, D., Kawamura, L. M., van Vollenhoven, A., Benike, C. J., Engleman, E. G. (1998). CTL Response to Mycobacterium tuberculosis: Identification of an Immunogenic Epitope in the 19-kDa Lipoprotein. J. Immunol. 161: 2400-2406 [Abstract] [Full Text]
Seitzman, G. D., Sonstein, J., Kim, S., Choy, W., Curtis, J. L. (1998). Lung Lymphocytes Proliferate Minimally in the Murine Pulmonary Immune Response to Intratracheal Sheep Erythrocytes. Am. J. Respir. Cell Mol. Bio. 18: 800-812 [Abstract] [Full Text]
Massard, G., Tongio, M.-M., Wihlm, J.-M., Morand, G. (1996). The Dendritic Cell Lineage: A Ubiquitous Antigen-Presenting Organization. Ann. Thorac. Surg. 61: 252-258 [Abstract] [Full Text]
Levine, B. W., Nickeleit, V. (1994). Case 5-1994- A 34-Year-Old Woman with Mild Exertional Dyspnea and Interstitial Pulmonary Lesions. NEJM 330: 347-353 [Full Text]
Shelhamer, J. H., Toews, G. B., Masur, H., Suffredini, A. F., Pizzo, P. A., Walsh, T. J., Henderson, D. K. (1992). Respiratory Disease in the Immunosuppressed Patient. ANN INTERN MED 117: 415-431 [Abstract]