Influence of the murine MHC (H-2) on Friend leukemia virus-induced immunosuppression

doi:10.1084/jem.163.2.301

This Article

	Full Text (PDF, 1015K)
	Alert me when this article is cited
	Citation Map

Services

	Email this article
	Similar articles in this journal
	Similar articles in PubMed
	Alert me to new content in the JEM
	Download to citation manager

Citing Articles

	Citing Articles via HighWire
	Citing Articles via CrossRef
	Citing Articles via Google Scholar

Google Scholar

	Articles by Morrison, R. P.
	Articles by Chesebro, B.
	Search for Related Content

PubMed

	PubMed Citation
	Articles by Morrison, R. P.
	Articles by Chesebro, B.


Social Bookmarking

	What's this?

ARTICLES

Influence of the murine MHC (H-2) on Friend leukemia virus-induced immunosuppression

RP Morrison, J Nishio and B Chesebro

Friend murine leukemia virus complex (FV)-induced immunosuppression was studied by assaying splenic anti-SRBC PFC responses and plasma antibody titers in mice at various times after FV inoculation. Genes located within the H-2 complex were found to influence resistance to FV-induced immunosuppression. Near normal responses were observed in mice having the H-2a/b or H-2b/b genotype, whereas mice having the H-2a/a genotype were suppressed. This H-2 effect was observed not only in mice having heterozygous C57BL/10 X A background genes, including Rfv-3r/s, but also was apparent in mice having homozygous A-strain background genes, including Rfv-3s/s. Therefore, the Rfv-3 gene did not appear to convey resistance to FV-induced immunosuppression. The suppression in susceptible H-2a/a mice was characterized by a partial suppression of the IgM response and a profound suppression of both the primary and secondary IgG responses. Neither splenomegaly nor viremia alone appeared to be sufficient for the induction or maintenance of the immunosuppression. The mechanism of suppression was unclear, but both B lymphocyte and T lymphocyte functions appeared to be altered.
Add to CiteULike CiteULike Add to Complore Complore Add to Connotea Connotea Add to Del.icio.us Del.icio.us Add to Digg Digg Facebook Add to Reddit Reddit Add to Technorati Technorati Twitter What's this?

This article has been cited by other articles:

Kawabata, H., Niwa, A., Tsuji-Kawahara, S., Uenishi, H., Iwanami, N., Matsukuma, H., Abe, H., Tabata, N., Matsumura, H., Miyazawa, M. (2006). Peptide-induced immune protection of CD8+ T cell-deficient mice against Friend retrovirus-induced disease. Int Immunol 18: 183-198 [Abstract] [Full Text]
Dittmer, U., Race, B., Peterson, K. E., Stromnes, I. M., Messer, R. J., Hasenkrug, K. J. (2002). Essential Roles for CD8+ T Cells and Gamma Interferon in Protection of Mice against Retrovirus-Induced Immunosuppression. J. Virol. 76: 450-454 [Abstract] [Full Text]
Iwanami, N., Niwa, A., Yasutomi, Y., Tabata, N., Miyazawa, M. (2001). Role of Natural Killer Cells in Resistance against Friend Retrovirus-Induced Leukemia. J. Virol. 75: 3152-3163 [Abstract] [Full Text]
Super, H. J., Hasenkrug, K. J., Simmons, S., Brooks, D. M., Konzek, R., Sarge, K. D., Morimoto, R. I., Jenkins, N. A., Gilbert, D. J., Copeland, N. G., Frankel, W., Chesebro, B. (1999). Fine Mapping of the Friend Retrovirus Resistance Gene, Rfv3, on Mouse Chromosome 15. J. Virol. 73: 7848-7852 [Abstract] [Full Text]
Super, H. J., Brooks, D., Hasenkrug, K., Chesebro, B. (1998). Requirement for CD4+ T Cells in the Friend Murine Retrovirus Neutralizing Antibody Response: Evidence for Functional T Cells in Genetic Low-Recovery Mice. J. Virol. 72: 9400-9403 [Abstract] [Full Text]
Dai, H. Y., Troseth, G. I., Gunleksrud, M., Bruland, T., Solberg, L. A., Aarset, H., Kristiansen, L. I., Dalen, A. (1998). Identification of Genetic Determinants Responsible for the Rapid Immunosuppressive Activity and the Low Leukemogenic Potential of a Variant of Friend Leukemia Virus, FIS-2. J. Virol. 72: 1244-1251 [Abstract] [Full Text]
Hasenkrug, K. J., Chesebro, B. (1997). Immunity to retroviral infection: The Friend virus�model. Proc. Natl. Acad. Sci. USA 94: 7811-7816 [Abstract] [Full Text]
Iwashiro, M., Messer, R. J., Peterson, K. E., Stromnes, I. M., Sugie, T., Hasenkrug, K. J. (2001). Immunosuppression by CD4+ regulatory T cells induced by chronic retroviral infection. Proc. Natl. Acad. Sci. USA 98: 9226-9230 [Abstract] [Full Text]