Journal of Experimental Medicine, Vol 162, 1015-1024, Copyright © 1985 by Rockefeller University Press

ARTICLES

Lymphoid tumors displaying rearrangements of both immunoglobulin and T cell receptor genes

PG Pelicci, DM Knowles 2d and R Dalla Favera

Ig and T beta gene rearrangements can be used as genetic markers of lineage and clonality in the study of B and T cell populations. We have addressed the issue of the respective B and T lineage specificity of these rearrangements by analyzing a panel of 63 lymphoid tumors representative of the various clinicopathologic categories of both B and T neoplasias. We report that approximately 10% of the cases tested displayed rearrangements of both Ig and T beta genes. Despite their dual genotypic pattern, these tumors retain a pure immunophenotype, i.e. they display either B or T cell lineage-restricted cell surface antigens. The implications of these findings for both normal and neoplastic lymphoid differentiation are discussed.
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