The Journal of Experimental Medicine
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Journal of Experimental Medicine, Vol 162, 768-773, Copyright © 1985 by Rockefeller University Press

ARTICLES

Antigen valence determines the binding of nominal antigen to cytolytic T cell clones

RF Siliciano, RM Colello, AD Keegan, RZ Dintzis, HM Dintzis and HS Shin

We have shown that cytotoxic T cell clones specific for the nominal antigen FL will bind high molecular weight (600,000 to 2,000,000) polyacrylamide and Ficoll polymers conjugated with 200-600 FL groups per molecule. Low molecular weight polymers (40,000) with the same epitope density did not give stable binding. A high molecular weight polymer with a lower epitope density also failed to bind. Taken together, these results suggest that a substantial degree of multivalence is a necessary factor in the stable binding of nominal antigen to T cell clones.
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