Journal of Experimental Medicine, Vol 161, 1219-1224, Copyright © 1985 by Rockefeller University Press

ARTICLES

Genetic markers of the antigen-specific T cell receptor locus

R Epstein, N Roehm, P Marrack, J Kappler, M Davis, S Hedrick and M Cohn

The restriction enzyme Eco RI reveals DNA cleavage sites that serve to distinguish the gene locus believed to encode the beta subunit of the major histocompatibility complex (MHC)-restricted, antigen-specific receptor of the T cell in BALB/c mice from that of SJL/J mice. A monoclonal antibody, KJ16-133, also distinguishes BALB/c and SJL/J, because it recognizes an allotypic marker present on a cell-surface heterodimer believed to function as the MHC-restricted, antigen- specific T cell receptor. This study has shown that these two markers cosegregate in a set of BALB/c X SJL/J recombinant inbred (RI) mouse strains, permitting the conclusion that they are linked to within 3 centimorgans of each other, and to the kappa locus on chromosome 6. The tight linkage between these independently derived, totally different T cell markers substantially strengthens the argument that they characterize the MHC-restricted antigen-specific receptor of the effector T cell.
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• Tillinghast, J., Behlke, M., Loh, D. (1986). Structure and diversity of the human T-cell receptor beta-chain variable region genes. Science 233: 879-883 [Abstract]  
• Behlke, M., Spinella, D., Chou, H., Sha, W, Hartl, D., Loh, D. (1985). T-cell receptor beta-chain expression: dependence on relatively few variable region genes. Science 229: 566-570 [Abstract]  

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