Heart-specific autoantibodies following murine coxsackievirus B3 myocarditis

doi:10.1084/jem.161.5.1112

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Heart-specific autoantibodies following murine coxsackievirus B3 myocarditis

LJ Wolfgram, KW Beisel and NR Rose

The sera from A.SW/SnJ mice infected with Coxsackievirus B3 (CB3) were tested on normal mouse tissue by indirect immunofluorescence. Heart- reactive antibodies were found. Absorption studies with organ extracts showed some of these autoantibodies to be heart-specific. Additional antibodies were crossreactive with skeletal muscle and kidney. These findings suggest a role for autoimmunity in the pathogenesis of murine CB3-induced myocarditis. This study establishes an animal model for the study of the humoral autoimmune response in human viral myocarditis.
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