Journal of Experimental Medicine, Vol 161, 748-754, Copyright © 1985 by Rockefeller University Press

ARTICLES

Hypohaptoglobinemia associated with familial epilepsy

SS Panter, SM Sadrzadeh, PE Hallaway, JL Haines, VE Anderson and JW Eaton

In select kindreds afflicted with familial idiopathic epilepsy, most individuals suffering seizures also have low levels of the plasma hemoglobin-binding protein, haptoglobin. This hypohaptoglobinemia may be causally associated with a tendency to develop epilepsy. Our experimental results indicate that artificially-induced hypohaptoglobinemia in mice causes retarded clearance of free hemoglobin from the central nervous system, and that such free hemoglobin may engender the peroxidation of brain lipids. We hypothesize that hypohaptoglobinemia, either inherited, or acquired via traumatic processes, may prevent efficient clearance of interstitial hemoglobin from the central nervous system, thereby predisposing these people to encephalic inflammation and the appearance of seizure disorders.
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This article has been cited by other articles:

• Sadrzadeh, S. M.H., Saffari, Y., Bozorgmehr, J. (2004). Haptoglobin Phenotypes in Epilepsy. Clin. Chem. 50: 1095-1097 [Full Text]  
• Langlois, M. R., Martin, M.-E., Boelaert, J. R., Beaumont, C., Taes, Y. E., De Buyzere, M. L., Bernard, D. R., Neels, H. M., Delanghe, J. R. (2000). The Haptoglobin 2-2 Phenotype Affects Serum Markers of Iron Status in Healthy Males. Clin. Chem. 46: 1619-1625 [Abstract] [Full Text]  
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