Journal of Experimental Medicine, Vol 160, 1931-1936, Copyright © 1984 by Rockefeller University Press

ARTICLES

Nonspecific recruitment of cytotoxic effector cells in the intestinal mucosa of antigen-primed mice

JR Klein and MF Kagnoff

We have examined cytotoxic responses of lymphocytes derived from the gut epithelium of mice primed systemically and enterically with alloantigens. Both gut intraepithelial (IEL) and splenic lymphocytes from alloantigen-primed mice were found to contain antigen-specific cytotoxic T cell activity. However, after priming, gut IEL also developed high levels of natural killer and spontaneous cytotoxic cell activities. We suggest that this nonspecific activation of additional cytotoxic effector populations during an antigen-specific response is an important host immune defense within the intestinal mucosa.
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