Response of resting human peripheral blood natural killer cells to interleukin 2

doi:10.1084/jem.160.4.1147

This Article

	Full Text (PDF, 1489K)
	Alert me when this article is cited
	Citation Map

Services

	Email this article
	Similar articles in this journal
	Similar articles in PubMed
	Alert me to new content in the JEM
	Download to citation manager

Citing Articles

	Citing Articles via HighWire
	Citing Articles via CrossRef
	Citing Articles via Google Scholar

Google Scholar

	Articles by Trinchieri, G.
	Articles by Perussia, B.
	Search for Related Content

PubMed

	PubMed Citation
	Articles by Trinchieri, G.
	Articles by Perussia, B.


Social Bookmarking

	What's this?

ARTICLES

Response of resting human peripheral blood natural killer cells to interleukin 2

G Trinchieri, M Matsumoto-Kobayashi, SC Clark, J Seehra, L London and B Perussia

The present study shows that recombinant interleukin 2 (IL-2) purified to homogeneity induces a rapid and potent enhancement of spontaneous cytotoxicity of human peripheral blood lymphocytes. The cells mediating cytotoxicity after 18-h treatment with IL-2 have surface markers of natural killer (NK) cells and are generated from the peripheral blood subset containing spontaneous cytotoxic cells. A parallel production of gamma interferon (IFN-gamma) is induced by recombinant IL-2 (rIL-2), and NK cells appear to be the major producer cells, whereas T cells are unable to produce IFN-gamma under these experimental conditions. However, the kinetics of the enhancement of cytotoxicity are faster than those of IFN-gamma production, and monoclonal anti-IFN-gamma antibodies do not suppress this effect, making it unlikely that the IFN- gamma produced is responsible for the enhancement. The enhancement of NK cell activity induced by rIL-2 precedes any proliferative response of the lymphocytes, which is instead observed in longer-term cultures of both NK and T cells.
Add to CiteULike CiteULike Add to Complore Complore Add to Connotea Connotea Add to Del.icio.us Del.icio.us Add to Digg Digg Facebook Add to Reddit Reddit Add to Technorati Technorati Twitter What's this?

This article has been cited by other articles:

Fujisaki, H., Kakuda, H., Shimasaki, N., Imai, C., Ma, J., Lockey, T., Eldridge, P., Leung, W. H., Campana, D. (2009). Expansion of Highly Cytotoxic Human Natural Killer Cells for Cancer Cell Therapy. Cancer Res. 69: 4010-4017 [Abstract] [Full Text]
Bryceson, Y. T., Rudd, E., Zheng, C., Edner, J., Ma, D., Wood, S. M., Bechensteen, A. G., Boelens, J. J., Celkan, T., Farah, R. A., Hultenby, K., Winiarski, J., Roche, P. A., Nordenskjold, M., Henter, J.-I., Long, E. O., Ljunggren, H.-G. (2007). Defective cytotoxic lymphocyte degranulation in syntaxin-11 deficient familial hemophagocytic lymphohistiocytosis 4 (FHL4) patients. Blood 110: 1906-1915 [Abstract] [Full Text]
Li, Z., Pradera, F., Kammertoens, T., Li, B., Liu, S., Qin, Z. (2007). Cross-Talk between T Cells and Innate Immune Cells Is Crucial for IFN-{gamma}-Dependent Tumor Rejection. J. Immunol. 179: 1568-1576 [Abstract] [Full Text]
Thoren, F. B., Romero, A. I., Hermodsson, S., Hellstrand, K. (2007). The CD16-/CD56bright Subset of NK Cells Is Resistant to Oxidant-Induced Cell Death. J. Immunol. 179: 781-785 [Abstract] [Full Text]
Imai, C., Iwamoto, S., Campana, D. (2005). Genetic modification of primary natural killer cells overcomes inhibitory signals and induces specific killing of leukemic cells. Blood 106: 376-383 [Abstract] [Full Text]
Solerte, S. B., Precerutti, S., Gazzaruso, C., Locatelli, E., Zamboni, M., Schifino, N., Bonacasa, R., Rondanelli, M., Taccani, D., Ferrari, E., Fioravanti, M. (2005). Defect of a subpopulation of natural killer immune cells in Graves' disease and Hashimoto's thyroiditis: normalizing effect of dehydroepiandrosterone sulfate. Eur J Endocrinol 152: 703-712 [Abstract] [Full Text]
Tenger, C., Sundborger, A., Jawien, J., Zhou, X. (2005). IL-18 Accelerates Atherosclerosis Accompanied by Elevation of IFN-{gamma} and CXCL16 Expression Independently of T Cells. Arterioscler. Thromb. Vasc. Bio. 25: 791-796 [Abstract] [Full Text]
Chan, W. L., Pejnovic, N., Hamilton, H., Liew, T. V., Popadic, D., Poggi, A., Khan, S. M. (2005). Atherosclerotic Abdominal Aortic Aneurysm and the Interaction Between Autologous Human Plaque-Derived Vascular Smooth Muscle Cells, Type 1 NKT, and Helper T Cells. Circ. Res. 96: 675-683 [Abstract] [Full Text]
Baeyens, A., Vandenbulcke, K., Philippe, J., Thierens, H., De Ridder, L., Vral, A. (2004). The use of IL-2 cultures to measure chromosomal radiosensitivity in breast cancer patients. Mutagenesis 19: 493-498 [Abstract] [Full Text]
Brignole, C., Pastorino, F., Marimpietri, D., Pagnan, G., Pistorio, A., Allen, T. M., Pistoia, V., Ponzoni, M. (2004). Immune Cell-Mediated Antitumor Activities of GD2-Targeted Liposomal c-myb Antisense Oligonucleotides Containing CpG Motifs. JNCI J Natl Cancer Inst 96: 1171-1180 [Abstract] [Full Text]
Takeda, K., Okumura, K. (2004). CAM and NK Cells. Evid Based Complement Alternat Med 1: 17-27 [Abstract] [Full Text]
Hess, S. D., Egilmez, N. K., Bailey, N., Anderson, T. M., Mathiowitz, E., Bernstein, S. H., Bankert, R. B. (2003). Human CD4+ T Cells Present Within the Microenvironment of Human Lung Tumors Are Mobilized by the Local and Sustained Release of IL-12 to Kill Tumors In Situ by Indirect Effects of IFN-{gamma}. J. Immunol. 170: 400-412 [Abstract] [Full Text]
Gerdes, N., Sukhova, G. K., Libby, P., Reynolds, R. S., Young, J. L., Schonbeck, U. (2002). Expression of Interleukin (IL)-18 and Functional IL-18 Receptor on Human Vascular Endothelial Cells, Smooth Muscle Cells, and Macrophages: Implications for Atherogenesis. JEM 195: 245-257 [Abstract] [Full Text]
Tsunobuchi, H., Nishimura, H., Goshima, F., Daikoku, T., Nishiyama, Y., Yoshikai, Y. (2000). Memory-Type CD8+ T Cells Protect IL-2 Receptor {alpha}-Deficient Mice from Systemic Infection with Herpes Simplex Virus Type 2. J. Immunol. 165: 4552-4560 [Abstract] [Full Text]
Wang, K. S., Frank, D. A., Ritz, J. (2000). Interleukin-2 enhances the response of natural killer cells to interleukin-12 through up-regulation of the interleukin-12 receptor and STAT4. Blood 95: 3183-3190 [Abstract] [Full Text]
Maxwell-Armstrong, C A, Durrant, L G, Robins, R A, Galvin, A M, Scholefield, J H, Hardcastle, J D (1999). Increased activation of lymphocytes infiltrating primary colorectal cancers following immunisation with the anti-idiotypic monoclonal antibody 105AD7. Gut 45: 593-598 [Abstract] [Full Text]
Kozlowski, M., Schorey, J., Portis, T., Grigoriev, V., Kornbluth, J. (1999). NK Lytic-Associated Molecule: A Novel Gene Selectively Expressed in Cells with Cytolytic Function. J. Immunol. 163: 1775-1785 [Abstract] [Full Text]
Cifone, M. G., D'Alo, S., Parroni, R., Millimaggi, D., Biordi, L., Martinotti, S., Santoni, A. (1999). Interleukin-2-Activated Rat Natural Killer Cells Express Inducible Nitric Oxide Synthase That Contributes to Cytotoxic Function and Interferon-gamma Production. Blood 93: 3876-3884 [Abstract] [Full Text]
Robertson, M. J., Cameron, C., Atkins, M. B., Gordon, M. S., Lotze, M. T., Sherman, M. L., Ritz, J. (1999). Immunological Effects of Interleukin 12 Administered by Bolus Intravenous Injection to Patients with Cancer. Clin. Cancer Res. 5: 9-16 [Abstract] [Full Text]
Zamai, L., Ahmad, M., Bennett, I. M., Azzoni, L., Alnemri, E. S., Perussia, B. (1998). Natural Killer (NK) Cell-mediated Cytotoxicity: Differential Use of TRAIL and Fas Ligand by Immature and Mature Primary Human NK Cells. JEM 188: 2375-2380 [Abstract] [Full Text]
Salvucci, O., Kolb, J. P., Dugas, B., Dugas, N., Chouaib, S. (1998). The Induction of Nitric Oxide by Interleukin-12 and Tumor Necrosis Factor-alpha in Human Natural Killer Cells: Relationship With the Regulation of Lytic Activity. Blood 92: 2093-2102 [Abstract] [Full Text]
Tomura, M., Zhou, X.-Y., Maruo, S., Ahn, H.-J., Hamaoka, T., Okamura, H., Nakanishi, K., Tanimoto, T., Kurimoto, M., Fujiwara, H. (1998). A Critical Role for IL-18 in the Proliferation and Activation of NK1.1+CD3- Cells. J. Immunol. 160: 4738-4746 [Abstract] [Full Text]
Fan, J., Nishanian, P., Breen, E. C., McDonald, M., Fahey, J. L. (1998). . CVI 5: 335-340 [Abstract]
Tomura, M., Maruo, S., Mu, J., Zhou, X.-Y., Ahn, H.-J., Hamaoka, T., Okamura, H., Nakanishi, K., Clark, S., Kurimoto, M., Fujiwara, H. (1998). Differential Capacities of CD4+, CD8+, and CD4-CD8- T Cell Subsets to Express IL-18 Receptor and Produce IFN-{gamma} in Response to IL-18. J. Immunol. 160: 3759-3765 [Abstract] [Full Text]
Nguyen, Q. H., Roberts, R. L., Ank, B. J., Lin, S.-J., Lau, C. K., Stiehm, E. R. (1998). Enhancement of Antibody-Dependent Cellular Cytotoxicity of Neonatal Cells by Interleukin-2 (IL-2) and IL-12. CVI 5: 98-104 [Abstract] [Full Text]
(1997). Corrections for vol. 184, p. 1845. JEM 185: 1149-1150 [Full Text]
Grabstein, K., Eisenman, J, Shanebeck, K, Rauch, C, Srinivasan, S, Fung, V, Beers, C, Richardson, J, Schoenborn, M., Ahdieh, M, et, al. (1994). Cloning of a T cell growth factor that interacts with the beta chain of the interleukin-2 receptor. Science 264: 965-968 [Abstract]
Takeshita, T, Asao, H, Ohtani, K, Ishii, N, Kumaki, S, Tanaka, N, Munakata, H, Nakamura, M, Sugamura, K (1992). Cloning of the gamma chain of the human IL-2 receptor. Science 257: 379-382 [Abstract]
Hsu, D., de Waal Malefyt, R, Fiorentino, D., Dang, M., Vieira, P, de Vries, J, Spits, H, Mosmann, T., Moore, K. (1990). Expression of interleukin-10 activity by Epstein-Barr virus protein BCRF1. Science 250: 830-832 [Abstract]
Tyring, S. K., Chopra, V., Johnson, L., Fine, J.-D. (1989). Natural Killer Cell Activity Is Reduced in Patients With Severe Forms of Inherited Epidermolysis Bullosa. Arch Dermatol 125: 797-800 [Abstract]
MURRAY, H. W. (1988). Interferon-Gamma, the Activated Macrophage, and Host Defense Against Microbial Challenge. ANN INTERN MED 108: 595-608 [Abstract]
Siegel, J., Sharon, M, Smith, P., Leonard, W. (1987). The IL-2 receptor beta chain (p70): role in mediating signals for LAK, NK, and proliferative activities. Science 238: 75-78 [Abstract]