The Journal of Experimental Medicine
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The Journal of Experimental Medicine, Vol 16, 303-314, Copyright, 1912, by The Rockefeller Institute for Medical Research New York

ARTICLE

NITROGEN AND NUCLEIN METABOLISM IN GOUT

P. A. Levene M.D.1 and Leo Kristeller M.D.1

1 From the Laboratories of The Rockefeller Institute for Medical Research and from the Montefiore Hospital, New York.

Thus, our conclusions harmonize with those of Brugsch and Schittenhelm in so far as they are concerned with the nuclein metabolism. They add, however, the observation that the elimination of nitrogenous substances of protein origin has a protracted character, and that the oxidation of as simple a substance as asparagin proceeds at a subnormal rate.

The most striking peculiarity observed in our patient was the very imperfect elimination of ingested urea when the patient was placed on a diet containing only six grams of nitrogen per day, and a much more complete elimination when the diet contained thirteen grams of nitrogen.

 Submitted on May 24, 1912


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