The Journal of Experimental Medicine
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Journal of Experimental Medicine, Vol 159, 1778-1783, Copyright © 1984 by Rockefeller University Press

ARTICLES

Sendai virus-specific T cell clones. V. Induction of a virus-specific response by antiidiotypic antibodies directed against a T helper cell clone

HC Ertl, E Homans, S Tournas and RW Finberg

We used an antiidiotypic antibody directed against a Sendai virus- specific T helper cell clone to stimulate an immune response in vivo. In addition, the antiidiotypic antibody induced T cells that mediated a delayed-type hypersensitivity (DTH) response in several different mouse strains. Induction of the DTH response by the antiidiotypic antibody, in contrast to the DTH responses induced by virus, demonstrated a remarkable lack of H-2 restriction.
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