The Journal of Experimental Medicine
VeriKine-HS Human IFN-Beta
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Journal of Experimental Medicine, Vol 159, 1283-1288, Copyright © 1984 by Rockefeller University Press

ARTICLES

Induction of idiotope suppression in the anti-azophenylarsonate response of T-depleted A/J mice

TL Rothstein, RA Miller, DJ Parker, E Kelly, AP Vastola and A Marshak-Rothstein

The homologous, monoclonal antiidiotope, MB, induced idiotope suppression that was remarkably stable and could be transferred by B lymphocytes. Marked depletion of T cell function, confirmed by limiting diluting analysis, did not affect the ability of MB to suppress the corresponding idiotope. Suppression induced by MB appears to result from direct interaction with idiotope-positive B cells, without the intervention of idiotope-specific T suppressor cells.
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