Mouse spleen dendritic cells present soluble antigens to antigen- specific T cell hybridomas

doi:10.1084/jem.158.5.1745

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Mouse spleen dendritic cells present soluble antigens to antigen- specific T cell hybridomas

GH Sunshine, DP Gold, HH Wortis, P Marrack and JW Kappler

In the presence of the soluble polypeptide antigens ovalbumin and keyhole limpet hemocyanin, purified mouse spleen dendritic cells induce the secretion of IL-2 by antigen-specific T cell hybridomas. This response is H-2 restricted and can be specifically inhibited by monoclonal anti-I-A. These data indicate that dendritic cells can present soluble antigen to H-2-compatible T cells.
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