Journal of Experimental Medicine, Vol 158, 1483-1497, Copyright © 1983 by Rockefeller University Press

ARTICLES

Role of the H-2 complex in the induction of T cell tolerance to self minor histocompatibility antigens

ES Groves and A Singer

The present study has utilized cytotoxic T lymphocyte (CTL) responses specific for minor histocompatibility (minor H) antigens as an experimental approach to determining whether recognition of self MHC determinants is involved in the induction of T cell tolerance to self antigens. It was observed that C3H.SW splenic T cells from C3H.SW leads to B10 X B10.BR radiation bone marrow chimeras contained CTL precursors (pCTL) reactive against self C3H minor H antigens + H-2k but were tolerant to self C3H minor H antigens + H-2b. Precursor CTL with the reciprocal reactivity pattern were observed for C3H leads to B10 X B10.BR chimeras. In addition, it was observed that C3H.SW thymocytes from C3H.SW leads to B10 X B10.BR chimeras could generate minor H- specific CTL responses and were reactive against self C3H minor H antigens + H-2k, but were tolerant to self C3H minor H antigens + H-2b. Thus, the present study demonstrates that for peripheral and intrathymic T cell populations at least a component of T cell tolerance to self antigens is restricted by products of the MHC.
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This article has been cited by other articles:

• Obst, R., Netuschil, N., Klopfer, K., Stevanovic, S., Rammensee, H.-G. (2000). The Role of Peptides in T Cell Alloreactivity Is Determined by Self-Major Histocompatibility Complex Molecules. JEM 191: 805-812 [Abstract] [Full Text]  
• Ramsdell, F, Fowlkes, B. (1990). Clonal deletion versus clonal anergy: the role of the thymus in inducing self tolerance. Science 248: 1342-1348 [Abstract]  
• Schild, H, Rotzschke, O, Kalbacher, H, Rammensee, H. (1990). Limit of T cell tolerance to self proteins by peptide presentation. Science 247: 1587-1589 [Abstract]  
• Ametani, A., Apple, R., Bhardwaj, V., Gammon, G., Miller, A., Sercarz, E. (1989). Examining the Crypticity of Antigenic Determinants. Cold Spring Harb Symp Quant Biol 54: 505-511 [Abstract]  

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