Journal of Experimental Medicine, Vol 158, 738-751, Copyright © 1983 by Rockefeller University Press
Regulatory mechanisms in cell-mediated immune responses. Role of I-J and I-C determinants in the activation of H-2I and H-2K/D alloantigen- specific suppressor T cells
S Rich
The role of individual H-2I subregion determinants in the activation of
H-2I alloantigen-primed mixed leukocyte response suppressor T cells (MLR
Ts), as well as their possible expression on stimulator cells required to
trigger primed H-2K- or D-specific MLR Ts, was addressed in these studies.
Both genetic and serologic studies demonstrated that MLR Ts potentially
primed to alloantigens encoded by the entire H-2I region were triggered to
MLR Ts factor production only by stimulator cells bearing the priming I-J
and/or I-C, but not I-A or I-E alloantigens. The relevant I-J and I-C
determinants were demonstrated on a single antigen-presenting cell
population that is used in common by independent I-J-specific and
I-C-specific MLR Ts. Unexpectedly, the stimulator cell population necessary
to trigger MLR Ts primed to class I H-2K or D alloantigens expressed not
only the priming class I determinant, but in addition, I-C alloantigens
syngeneic with the MLR Ts haplotype. Stimulator populations bearing the
appropriate H-2K or D alloantigen but serologically depleted of I-C+ cells
or genetically constructed to display MLR Ts-disparate I-C determinants
were ineffective stimulators of class I antigen-primed MLR Ts. Thus these
data suggest that as allogeneic determinants, I-J- and I-C-encoded
molecules are together the major triggering elements for MLR Ts primed to
disparate H-2I region determinants. In addition, self-I-C molecule
recognition appears to constitute an important feature of the triggering,
and by implication, priming process of H-2 class I antigen- specific Ts
cells.
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