Journal of Experimental Medicine, Vol 158, 506-514, Copyright © 1983 by Rockefeller University Press
Suppression of endogenous murine leukemia virus by maternal resistance factor
M Melamedoff, F Lilly and ML Duran-Reynals
Females of the RF and SJL inbred mouse strains transmit to their progeny of
both sexes a nonmendelian maternal resistance factor (MRF) able to suppress
the expression of endogenous ecotropic murine leukemia virus (E-MuLV). This
MRF is demonstrable in crosses with AKR mice by comparing E-MuLV expression
in the spleens and thymuses of reciprocal F1 generations. DBA/2 and ST/b
mice are MRF negative by these criteria. Neonatal inoculation of
E-MuLV-containing spleen extracts gives rise to persistent expression of
infectious virus in mice of the MRF- but not the MRF+ strains. However,
inoculation of the virus in 30-d-old females of the MRF- strains no longer
leads to a state of persistent infection; instead, these females become
MRF+ and transmit protection against E- MuLV expression to their progeny by
AKR and RF males. The MRF appears to be transmitted to the progeny mainly
through the milk, since foster- nursing AKR neonates on RF (but not DBA/2)
mothers greatly reduces E- MuLV expression in the progeny. These
RF-fostered AKR mice also show a reduced and delayed lymphoma incidence, a
finding consistent with the idea that maternally transmitted resistance to
E-MuLV expression is the basis for the classic maternal resistance to
lymphomagenesis seen in the progeny of RF mothers.
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