The Journal of Experimental Medicine
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Journal of Experimental Medicine, Vol 158, 258-263, Copyright © 1983 by Rockefeller University Press

ARTICLES

Complement receptor mediates enhanced flavivirus replication in macrophages

MJ Cardosa, JS Porterfield and S Gordon

Evidence is presented that M phi complement receptors (CR3) mediate IgM- dependent enhancement of flavivirus replication in the presence of complement. Enhancement is blocked by pretreatment of macrophages with monoclonal antibody Ml/70, which inhibits CR3 binding, but not by pretreatment with monoclonal antibody 2.4G2, which inhibits FcR binding.
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