The Journal of Experimental Medicine
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Journal of Experimental Medicine, Vol 157, 947-956, Copyright © 1983 by Rockefeller University Press

ARTICLES

Synthetic Fc peptide-mediated regulation of the immune response. I. Characterization of the immunomodulating properties of a synthetic 23- amino acid peptide derived from the sequence of the CH3 domain of human IgG1

EL Morgan, JE Shields, CS Campbell, RL Barton, GA Koppel and WO Weigle

A synthetic 23-amino acid peptide derived from the CH3 domain of human IgG1 was found to be a potent adjuvant as well as a polyclonal activator. The Fc peptide was found to enhance human and murine humoral, and T cell-mediated immune responses. Moreover, in vivo administration of Fc peptide enhanced murine natural killer cell activity. The synthetic Fc peptide was found to be more potent, on a molar basis, than native Fc fragments in inducing polyclonal antibody production and potentiating immune responses.
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