The Journal of Experimental Medicine
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Journal of Experimental Medicine, Vol 157, 1059-1063, Copyright © 1983 by Rockefeller University Press

ARTICLES

Immune human lymphocytes produce an acid-labile alpha -interferon

FR Balkwill, DB Griffin, HA Band, and PCL Beverley

We have described in this paper a novel human interferon (IFN) with antigenic and cross-species reactivity of alpha -IFN and physicochemical properties of gamma -IFN. This IFN is produced by normal peripheral blood mononuclear cells during an immune response but has also been associated with autoimmune disease (10). The system described here will be useful in elucidating the biological significance and cell of origin of this IFN.
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