The Journal of Experimental Medicine
Torrey Pines Biolabs
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*Melanoma
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Journal of Experimental Medicine, Vol 156, 1884-1889, Copyright © 1982 by Rockefeller University Press

ARTICLES

Human melanoma antigen AH is an autoantigenic ganglioside related to GD2

T Watanabe, CS Pukel, H Takeyama, KO Lloyd, H Shiku, LT Li, LR Travassos, HF Oettgen and LJ Old

AH antigen, initially defined by an antibody present in a melanoma patient, is a cell surface antigen found on approximately 65% of melanoma cell lines. Absorption analysis indicates that AH is a differentiation antigen marking normal and malignant cells of neuroectodermal origin. The AH determinant has been found to be related to GD2 ganglioside.
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