Suppression of hyperbilirubinemia in the rat neonate by chromium- protoporphyrin. Interactions of metalloporphyrins with microsomal heme oxygenase of human spleen

doi:10.1084/jem.156.6.1878

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Suppression of hyperbilirubinemia in the rat neonate by chromium- protoporphyrin. Interactions of metalloporphyrins with microsomal heme oxygenase of human spleen

GS Drummond and A Kappas

The synthetic metalloporphyrin, Cr-protoporphyrin, as a potent competitive inhibitor of heme oxygenase activity in rat spleen, liver, and kidney. When administered to neonatal animals in a single dose immediately after birth, Cr-protoporphyrin suppresses postnatal hyperbilirubinemia and produces a marked and sustained lowering of heme oxidation activity in liver, spleen, and kidney. The metalloporphyrin also potently inhibited the rate of heme degradation to bile pigment in human spleen.
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Wong, R. J., Bhutani, V. K., Vreman, H. J., Stevenson, D. K. (2007). Pharmacology Review: Tin Mesoporphyrin for the Prevention of Severe Neonatal Hyperbilirubinemia. NeoReviews 8: e77-e84 [Abstract] [Full Text]