The Journal of Experimental Medicine
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Journal of Experimental Medicine, Vol 156, 1854-1859, Copyright © 1982 by Rockefeller University Press

ARTICLES

Helper cell-independent cytotoxic clones in man

SL Wee, LK Chen, G Strassmann and FH Bach

We report here a class of helper cell-independent cytotoxic T cell (HITc) clones in man that can proliferate in response to antigenic stimulation as well as mediate cytotoxicity. HITc appear to be rare among clones derived from primary in vitro allosensitized culture, but constitute the majority of clones derived from cells sensitized to autologous Epstein-Barr virus-transformed lymphoblastoid cell lines. The implications of the derivation and function of HITc clones are discussed.
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