The Journal of Experimental Medicine
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Journal of Experimental Medicine, Vol 156, 1131-1148, Copyright © 1982 by Rockefeller University Press

ARTICLES

Mutant monoclonal antibodies with alterations in biological functions

DE Yelton and MD Scharff

Somatic cell mutants with deletions in the immunoglobulin constant region were isolated from an IgG(2b) Ar-binding hybridoma. Rat anti-mouse immunoglobulins were used to identify the sites of the deletions. The mutant monoclonal antibodies differ from the parental molecule in their assembly states and are defective in various immunoglobulin activities, making them potentially more useful reagents.
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