The Journal of Experimental Medicine
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Journal of Experimental Medicine, Vol 155, 1334-1343, Copyright © 1982 by Rockefeller University Press

ARTICLES

Non-H-2 restriction of expression of passively transferred delayed sensitivity

PA Berche and RJ North

The results of this study of allogeneic restriction of passively transferred delayed sensitivity to Listeria antigens serve to illustrate the complexity of in vivo models. They show that the H-2 restriction observed when delayed-type hypersensitivity was transferred between H-2-congenic strains was no more severe than the restriction observed when delayed-type hypersensitivity was transferred between parental and F1 mice and between different strains sharing the same H-2 haplotype. It is obvious that genes, in addition to those of the H-2 locus, can be responsible for allogeneic restriction in vivo.
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