The Journal of Experimental Medicine
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Journal of Experimental Medicine, Vol 155, 1204-1209, Copyright © 1982 by Rockefeller University Press

ARTICLES

Antigen-specific production of immune interferon by T Cells lines

JL McKimm-Breschkin, PL Mottram, WR Thomas and JF Miller

Continuous cultures of T cells reactive to the hapten 4-ethoxymethylene- 2-phenyloxazolone were tested for interferon production after antigenic stimulation in vitro. Induction of interferon was antigen-specific and also restricted by the I region of the major histocompatibility complex. Kinetics of antigen induced interferon production were different from those reported for mitogen induced synthesis.
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