The Journal of Experimental Medicine
Torrey Pines Biolabs
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Journal of Experimental Medicine, Vol 154, 1970-1974, Copyright © 1981 by Rockefeller University Press

ARTICLES

T cell clones with dual specificity for M1s and various major histocompatibility complex determinants

SR Webb, K Molnar-Kimber, J Bruce, J Sprent and DB Wilson

A high proportion of T cell clones derived from bulk cultures selected to M1s a,d determinants were found to have joint specificity for allo-H- 2 determinants, and vice versa. Significantly, the patterns of H-2 alloreactivity shown by clones selected to M1sa,b determinants appeared to be random. The possible implications of these findings are discussed.
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