Journal of Experimental Medicine, Vol 154, 1965-1969, Copyright © 1981 by Rockefeller University Press

ARTICLES

The nature of the immunoglobulin G on the surface of B lymphocytes in chronic lymphocytic leukemia

FK Stevenson, TJ Hamblin and GT Stevenson

The nature of the immunoglobulin (Ig) G found associated with the neoplastic B lymphocytes in chronic lymphocytic leukemia that also express Igm and IgD had been investigated by absorption studies using anti-idiotypic antibodies raised against cell surface IgM from five patients. In all five cases, although cellular IgM and IgD behaved as idiotypic, the IgG did not. Thus the IgG frequently found associated with lymphocytes at this stage of differentiation is likely, at least in many cases, to be of extrinsic origin.
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This article has been cited by other articles:

• Ottensmeier, C. H., Thompsett, A. R., Zhu, D., Wilkins, B. S., Sweetenham, J. W., Stevenson, F. K. (1998). Analysis of VH Genes in Follicular and Diffuse Lymphoma Shows Ongoing Somatic Mutation and Multiple Isotype Transcripts in Early Disease With Changes During Disease Progression. Blood 91: 4292-4299 [Abstract] [Full Text]  
• Sahota, S. S., Garand, R., Bataille, R., Smith, A. J., Stevenson, F. K. (1998). VH Gene Analysis of Clonally Related IgM and IgG From Human Lymphoplasmacytoid B-Cell Tumors With Chronic Lymphocytic Leukemia Features and High Serum Monoclonal IgG. Blood 91: 238-243 [Abstract] [Full Text]  
• GALE, R. P., FOON, K. A. (1985). Chronic Lymphocytic Leukemia: Recent Advances in Biology and Treatment. ANN INTERN MED 103: 101-120 [Abstract]  

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