Detection of the human T cell lymphoma virus p19 in cells of some patients with cutaneous T cell lymphoma and leukemia using a monoclonal antibody

doi:10.1084/jem.154.6.1957

This Article

	Full Text (PDF, 1002K)
	Alert me when this article is cited
	Citation Map

Services

	Email this article
	Similar articles in this journal
	Similar articles in PubMed
	Alert me to new content in the JEM
	Download to citation manager

Citing Articles

	Citing Articles via HighWire
	Citing Articles via CrossRef
	Citing Articles via Google Scholar

Google Scholar

	Articles by Robert-Guroff, M.
	Articles by Gallo, R. C.
	Search for Related Content

PubMed

	PubMed Citation
	Articles by Robert-Guroff, M.
	Articles by Gallo, R. C.


Social Bookmarking

	What's this?

ARTICLES

Detection of the human T cell lymphoma virus p19 in cells of some patients with cutaneous T cell lymphoma and leukemia using a monoclonal antibody

M Robert-Guroff, FW Ruscetti, LE Posner, BJ Poiesz and RC Gallo

A monoclonal antibody specific for the internal p19 protein of a type-C retrovirus (HTLV) isolated from human neoplastic T cells has been developed. Its specificity has been shown by radioimmune precipitation and by affinity chromatography of iodinated HTLV proteins. By indirect immune fluorescence this antibody recognizes only HTLV-producing cells. Examination of cells from patients with cutaneous T cell lymphomas and leukemias and with other types of lymphomas and leukemias indicated that HTLV p19 expression is rare. The monoclonal antibody will be useful in determining the natural reservoir of HTLV, possibly in a subset of mature T cell neoplasias.
Add to CiteULike CiteULike Add to Complore Complore Add to Connotea Connotea Add to Del.icio.us Del.icio.us Add to Digg Digg Facebook Add to Reddit Reddit Add to Technorati Technorati Twitter What's this?

This article has been cited by other articles:

Gorham, E. D., Garland, F. C., Mayers, D. L., Goforth, R. R., Brodine, S. K., Weiss, P. J., McNally, M. S., Navy Retroviral Working Group, (1993). CD4 Lymphocyte Counts Within 24 Months of Human Immunodeficiency Virus Seroconversion: Findings in the US Navy and Marine Corps. Arch Intern Med 153: 869-876 [Abstract]
Tuyp, E., Burgoyne, A., Aitchison, T., MacKie, R. (1987). A Case-Control Study of Possible Causative Factors in Mycosis Fungoides. Arch Dermatol 123: 196-200 [Abstract]
Gartner, S., Markovits, P., Markovitz, D. M., Betts, R. F., Popovic, M. (1986). Virus Isolation From and Identification of HTLV-III/LAV-Producing Cells in Brain Tissue From a Patient With AIDS. JAMA 256: 2365-2371 [Abstract]
Gartner, S, Markovits, P, Markovitz, D., Kaplan, M., Gallo, R., Popovic, M (1986). The role of mononuclear phagocytes in HTLV-III/LAV infection. Science 233: 215-219 [Abstract]
Felber, B., Paskalis, H, Kleinman-Ewing, C, Wong-Staal, F, Pavlakis, G. (1985). The pX protein of HTLV-I is a transcriptional activator of its long terminal repeats. Science 229: 675-679 [Abstract]
Goh, W., Sodroski, J, Rosen, C, Essex, M, Haseltine, W. (1985). Subcellular localization of the product of the long open reading frame of human T-cell leukemia virus type I. Science 227: 1227-1228 [Abstract]
Sodroski, J, Rosen, C, Wong-Staal, F, Salahuddin, S., Popovic, M, Arya, S, Gallo, R., Haseltine, W. (1985). Trans-acting transcriptional regulation of human T-cell leukemia virus type III long terminal repeat. Science 227: 171-173 [Abstract]
Popovic, M, Flomenberg, N, Volkman, D., Mann, D, Fauci, A., Dupont, B, Gallo, R. (1984). Alteration of T-cell functions by infection with HTLV-I or HTLV-II. Science 226: 459-462 [Abstract]
Saxinger, W, Blattner, W., Levine, P., Clark, J, Biggar, R, Hoh, M, Moghissi, J, Jacobs, P, Wilson, L, Jacobson, R, et, al. (1984). Human T-cell leukemia virus (HTLV-I) antibodies in Africa. Science 225: 1473-1476 [Abstract]
PALMER, E. L., RAMSEY, R. B., FEORINO, P. F., HARRISON, A. K., CABRADILLA, C., FRANCIS, D. P., POON, M.-C., EVATT, B. L. (1984). Human T-Cell Leukemia Virus in Lymphocytes of Two Hemophiliacs with the Acquired Immunodeficiency Syndrome. ANN INTERN MED 101: 293-297 [Abstract]
Levy, J., Hoffman, A., Kramer, S., Landis, J., Shimabukuro, J., Oshiro, L. (1984). Isolation of lymphocytopathic retroviruses from San Francisco patients with AIDS. Science 225: 840-842 [Abstract]
Sodroski, J., Rosen, C., Haseltine, W. (1984). Trans-acting transcriptional activation of the long terminal repeat of human T lymphotropic viruses in infected cells. Science 225: 381-385 [Abstract]
Haseltine, W., Sodroski, J, Patarca, R, Briggs, D, Perkins, D, Wong-Staal, F (1984). Structure of 3' terminal region of type II human T lymphotropic virus: evidence for new coding region. Science 225: 419-421 [Abstract]
Sodroski, J, Patarca, R, Perkins, D, Briggs, D, Lee, T., Essex, M, Coligan, J, Wong-Staal, F, Gallo, R., Haseltine, W. (1984). Sequence of the envelope glycoprotein gene of type II human T lymphotropic virus. Science 225: 421-424 [Abstract]
BRODER, S., BUNN, P. A. Jr., JAFFE, E. S., BLATTNER, W., GALLO, R. C., WONG-STAAL, F., WALDMANN, T. A., DeVITA, V. T. Jr. (1984). T-Cell Lymphoproliferative Syndrome Associated with Human T-Cell Leukemia/Lymphoma Virus. ANN INTERN MED 100: 543-557 [Abstract]
Clapham, P, Nagy, K, Cheingsong-Popov, R, Exley, M, Weiss, R. (1983). Productive infection and cell-free transmission of human T-cell leukemia virus in a nonlymphoid cell line. Science 222: 1125-1127 [Abstract]
METROKA, C. E., MOURADIAN, J., CUNNINGHAM-RUNDLES, S. (1983). The Acquired Immunodeficiency Syndrome. ANN INTERN MED 99: 734-736 [Abstract]
Blattner, W. A., Takatsuki, K., Gallo, R. C. (1983). Human T-Cell Leukemia-Lymphoma Virus and Adult T-Cell Leukemia. JAMA 250: 1074-1080 [Abstract]
Gallo, R., Sarin, P., Gelmann, E., Robert-Guroff, M, Richardson, E, Kalyanaraman, V., Mann, D, Sidhu, G., Stahl, R., Zolla-Pazner, S, Leibowitch, J, Popovic, M (1983). Isolation of human T-cell leukemia virus in acquired immune deficiency syndrome (AIDS). Science 220: 865-867 [Abstract]
Barre-Sinoussi, F, Chermann, J., Rey, F, Nugeyre, M., Chamaret, S, Gruest, J, Dauguet, C, Axler-Blin, C, Vezinet-Brun, F, Rouzioux, C, Rozenbaum, W, Montagnier, L (1983). Isolation of a T-lymphotropic retrovirus from a patient at risk for acquired immune deficiency syndrome (AIDS). Science 220: 868-871 [Abstract]
Popovic, M, Sarin, P., Robert-Gurroff, M, Kalyanaraman, V., Mann, D, Minowada, J, Gallo, R. (1983). Isolation and transmission of human retrovirus (human t-cell leukemia virus). Science 219: 856-859 [Abstract]
Nowinski, R., Tam, M., Goldstein, L., Stong, L, Kuo, C., Corey, L, Stamm, W., Handsfield, H., Knapp, J., Holmes, K. (1983). Monoclonal antibodies for diagnosis of infectious diseases in humans. Science 219: 637-644
BLAYNEY, D. W., JAFFE, E. S., FISHER, R. I., SCHECHTER, G. P., COSSMAN, J., ROBERT-GUROFF, M., KALYANARAMAN, V. S., BLATTNER, W. A., GALLO, R. C. (1983). The Human T-cell Leukemia/Lymphoma Virus, Lymphoma, Lytic Bone Lesions, and Hypercalcemia. ANN INTERN MED 98: 144-151 [Abstract]
Kalyanaraman, V., Sarngadharan, M., Robert-Guroff, M, Miyoshi, I, Golde, D, Gallo, R. (1982). A new subtype of human T-cell leukemia virus (HTLV-II) associated with a T-cell variant of hairy cell leukemia. Science 218: 571-573 [Abstract]