Distribution of common acute lymphoblastic leukemia antigen in nonhematopoietic tissues

doi:10.1084/jem.154.4.1249

This Article

	Full Text (PDF, 953K)
	Alert me when this article is cited
	Citation Map

Services

	Email this article
	Similar articles in this journal
	Similar articles in PubMed
	Alert me to new content in the JEM
	Download to citation manager

Citing Articles

	Citing Articles via HighWire
	Citing Articles via CrossRef
	Citing Articles via Google Scholar

Google Scholar

	Articles by Metzgar, R. S.
	Articles by Dowell, B. L.
	Search for Related Content

PubMed

	PubMed Citation
	Articles by Metzgar, R. S.
	Articles by Dowell, B. L.


Social Bookmarking

	What's this?

ARTICLES

Distribution of common acute lymphoblastic leukemia antigen in nonhematopoietic tissues

RS Metzgar, MJ Borowitz, NH Jones and BL Dowell

The common acute lymphoblastic leukemia antigen (CALLA), as defined by J-5 murine monoclonal antibodies, was detected on renal tubular and glomerular cells from fetal and adult donors by an indirect immunoperoxidase technique. CALLA could also be detected on epithelial cells of the fetal small intestine and on myoepithelial cells of adult breast but not on myoepithelial cells of the salivary gland. Sodium dodecyl sulfate-polyacrylamide gel electrophoresis analysis of immunoprecipitated 125I-labeled membrane antigens from dissociated renal cells demonstrated that the antigen migrated as a 90,000 mol wt antigen rather than the 98,000-100,000 mol wt antigen noted on CALLA- positive tissue culture cell lines. The data suggest that the determinant defined by the J-5 monoclonal antibody is neither a lymphoid cell-specific differentiation antigen nor a leukemia-specific antigen.
Add to CiteULike CiteULike Add to Complore Complore Add to Connotea Connotea Add to Del.icio.us Del.icio.us Add to Digg Digg Facebook Add to Reddit Reddit Add to Technorati Technorati Twitter What's this?

This article has been cited by other articles:

Ronco, P., Debiec, H. (2005). Molecular Pathomechanisms of Membranous Nephropathy: From Heymann Nephritis to Alloimmunization. J. Am. Soc. Nephrol. 16: 1205-1213 [Abstract] [Full Text]
Kalof, A N, Tam, D, Beatty, B, Cooper, K (2004). Immunostaining patterns of myoepithelial cells in breast lesions: a comparison of CD10 and smooth muscle myosin heavy chain. J. Clin. Pathol. 57: 625-629 [Abstract] [Full Text]
Debiec, H., Guigonis, V., Mougenot, B., Haymann, J.-P., Bensman, A., Deschenes, G., Ronco, P. M. (2003). Antenatal Membranous Glomerulonephritis with Vascular Injury Induced by Anti-Neutral Endopeptidase Antibodies: Toward New Concepts in the Pathogenesis of Glomerular Diseases. J. Am. Soc. Nephrol. 14: S27-32 [Full Text]
Debiec, H., Guigonis, V., Mougenot, B., Decobert, F., Haymann, J.-P., Bensman, A., Deschenes, G., Ronco, P. M. (2002). Antenatal Membranous Glomerulonephritis Due to Anti-Neutral Endopeptidase Antibodies. NEJM 346: 2053-2060 [Full Text]
Cutrona, G., Leanza, N., Ulivi, M., Melioli, G., Burgio, V. L., Mazzarello, G., Gabutti, G., Roncella, S., Ferrarini, M. (1999). Expression of CD10 by Human T Cells That Undergo Apoptosis Both In Vitro and In Vivo. Blood 94: 3067-3076 [Abstract] [Full Text]
Greaves, M. (1986). Differentiation-linked leukemogenesis in lymphocytes. Science 234: 697-704 [Abstract]
Insel, R. A., Gigliotti, F. (1983). Monoclonal Antibodies: Clinical Relevance to Pediatrics. Arch Pediatr Adolesc Med 137: 69-76 [Abstract]