Virus-specific interferon action. Protection of newborn Mx carriers against lethal infection with influenza virus

doi:10.1084/jem.154.1.199

This Article

	Full Text (PDF, 287K)
	Alert me when this article is cited
	Citation Map

Services

	Email this article
	Similar articles in this journal
	Similar articles in PubMed
	Alert me to new content in the JEM
	Download to citation manager

Citing Articles

	Citing Articles via HighWire
	Citing Articles via CrossRef
	Citing Articles via Google Scholar

Google Scholar

	Articles by Haller, O.
	Articles by Lindenmann, J.
	Search for Related Content

PubMed

	PubMed Citation
	Articles by Haller, O.
	Articles by Lindenmann, J.


Social Bookmarking

	What's this?

ARTICLES

Virus-specific interferon action. Protection of newborn Mx carriers against lethal infection with influenza virus

O Haller, H Arnheiter, I Gresser and J Lindenmann

The efficacy of interferon in antiviral protection of newborn mice differing at the Mx locus was investigated. Adult mice bearing the allele Mx exhibit a high degree of specific resistance toward lethal challenge with influenza viruses. In contrast, newborn Mx carriers are virtually as susceptible to influenza viruses as newborn mice devoid of Mx. Resistance can be abrogated by treating adult animals with anti- interferon serum. Here, we provide direct evidence of a virus-specific effect of interferon in vivo: newborn mice carrying the resistance gene Mx could be protected against lethal influenza virus infection with doses of interferon that were not protective in the absence of Mx. The efficacy of interferon towards a picornavirus (encephalomyocarditis virus) and a rhabdovirus (vesicular stomatitis virus) was independent of Mx.
Add to CiteULike CiteULike Add to Complore Complore Add to Connotea Connotea Add to Del.icio.us Del.icio.us Add to Digg Digg Facebook Add to Reddit Reddit Add to Technorati Technorati Twitter What's this?

This article has been cited by other articles:

Dittmann, J., Stertz, S., Grimm, D., Steel, J., Garcia-Sastre, A., Haller, O., Kochs, G. (2008). Influenza A Virus Strains Differ in Sensitivity to the Antiviral Action of Mx-GTPase. J. Virol. 82: 3624-3631 [Abstract] [Full Text]
Carroll, T. D., Matzinger, S. R., Genesca, M., Fritts, L., Colon, R., McChesney, M. B., Miller, C. J. (2008). Interferon-Induced Expression of MxA in the Respiratory Tract of Rhesus Macaques Is Suppressed by Influenza Virus Replication. J. Immunol. 180: 2385-2395 [Abstract] [Full Text]
Grimm, D., Staeheli, P., Hufbauer, M., Koerner, I., Martinez-Sobrido, L., Solorzano, A., Garcia-Sastre, A., Haller, O., Kochs, G. (2007). Replication fitness determines high virulence of influenza A virus in mice carrying functional Mx1 resistance gene. Proc. Natl. Acad. Sci. USA 104: 6806-6811 [Abstract] [Full Text]
Vernon, P. S., Griffin, D. E. (2005). Characterization of an In Vitro Model of Alphavirus Infection of Immature and Mature Neurons. J. Virol. 79: 3438-3447 [Abstract] [Full Text]
Pichlmair, A., Buse, J., Jennings, S., Haller, O., Kochs, G., Staeheli, P. (2004). Thogoto Virus Lacking Interferon-Antagonistic Protein ML Is Strongly Attenuated in Newborn Mx1-Positive but Not Mx1-Negative Mice. J. Virol. 78: 11422-11424 [Abstract] [Full Text]
Vollstedt, S., Franchini, M., Hefti, H. P., Odermatt, B., O'Keeffe, M., Alber, G., Glanzmann, B., Riesen, M., Ackermann, M., Suter, M. (2003). Flt3 Ligand-treated Neonatal Mice Have Increased Innate Immunity Against Intracellular Pathogens and Efficiently Control Virus Infections. JEM 197: 575-584 [Abstract] [Full Text]