Bone marrow origin of Ia-positive cells in the medulla rat thymus

doi:10.1084/jem.153.6.1666

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Bone marrow origin of Ia-positive cells in the medulla rat thymus

AN Barclay and G Mayrhofer

Irradiated rats were reconstituted with bone marrow from F1 hybrids. Ia antigen of donor-bone marrow origin was detected by an immunoperoxidase technique on cryostat sections and found predominantly in the medulla of rat thymus 2 wk after reconstitution. These Ia-bearing cells increased in number with time after reconstitution, but the Ia on the cortical epithelial cells remained of host origin. The nature of the bone marrow-derived cells and their implication for major histocompatibility complex restriction are discussed.
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