Induction of anterior chamber-associated immune deviation requires an intact, functional spleen

doi:10.1084/jem.153.5.1058

This Article

	Full Text (PDF, 606K)
	Alert me when this article is cited
	Citation Map

Services

	Email this article
	Similar articles in this journal
	Similar articles in PubMed
	Alert me to new content in the JEM
	Download to citation manager

Citing Articles

	Citing Articles via HighWire
	Citing Articles via CrossRef
	Citing Articles via Google Scholar

Google Scholar

	Articles by Streilein, J. W.
	Articles by Niederkorn, J. Y.
	Search for Related Content

PubMed

	PubMed Citation
	Articles by Streilein, J. W.
	Articles by Niederkorn, J. Y.


Social Bookmarking

	What's this?

ARTICLES

Induction of anterior chamber-associated immune deviation requires an intact, functional spleen

JW Streilein and JY Niederkorn

Anterior chamber-associated immune deviation (ACAID) expresses itself in BALB/c mice inoculated intracamerally with P815 cells in three ways: progressive growth of the tumor within the eye, transient growth of P815 cells injected subcutaneously, and prolonged acceptance of DBA/2 skin allografts. The spleen was found to play a crucial role in the development of ACAID. Splenectomized animals bearing intracameral P815 tumors reject DBA/2 skin grafts in an accelerated manner. A functioning spleen was required during the first 10 d after intracameral inoculation of P815 cells, but not thereafter. Reconstitution experiments revealed that the spleen's ability to support the induction of ACAID depends partly upon its constituent lymphoid cells, but also upon either a stromal component or a unique architectural arrangement that can only be restored with splenic fragments. The data hold promise that therapeutic protocols using appropriately timed splenectomy and specific immunization can be devised to induce hosts bearing intraocular tumors to mount an immune response sufficiently vigorous to destroy the tumor within the eye, and sufficiently precise to preserve the functional and anatomic integrity of the eye.
Add to CiteULike CiteULike Add to Complore Complore Add to Connotea Connotea Add to Del.icio.us Del.icio.us Add to Digg Digg Facebook Add to Reddit Reddit Add to Technorati Technorati Twitter What's this?

This article has been cited by other articles:

Watte, C. M., Nakamura, T., Lau, C. H., Ortaldo, J. R., Stein-Streilein, J. (2008). Ly49 C/I-dependent NKT cell-derived IL-10 is required for corneal graft survival and peripheral tolerance. J. Leukoc. Biol. 83: 928-935 [Abstract] [Full Text]
Gregory, M. S., Saff, R. R., Marshak-Rothstein, A., Ksander, B. R. (2007). Control of Ocular Tumor Growth and Metastatic Spread by Soluble and Membrane Fas Ligand. Cancer Res. 67: 11951-11958 [Abstract] [Full Text]
Meng, Q., Yang, P., Li, B., Zhou, H., Huang, X., Zhu, L., Ren, Y., Kijlstra, A. (2006). CD4+PD-1+ T Cells Acting as Regulatory Cells during the Induction of Anterior Chamber-Associated Immune Deviation.. IOVS 47: 4444-4452 [Abstract] [Full Text]
Ashour, H. M., Niederkorn, J. Y. (2006). Peripheral Tolerance Via the Anterior Chamber of the Eye: Role of B Cells in MHC Class I and II Antigen Presentation. J. Immunol. 176: 5950-5957 [Abstract] [Full Text]
Camelo, S., Kezic, J., Shanley, A., Rigby, P., McMenamin, P. G. (2006). Antigen from the Anterior Chamber of the Eye Travels in a Soluble Form to Secondary Lymphoid Organs via Lymphatic and Vascular Routes.. IOVS 47: 1039-1046 [Abstract] [Full Text]
Mimura, T., Yokoo, S., Araie, M., Amano, S., Yamagami, S. (2005). Treatment of Rabbit Bullous Keratopathy with Precursors Derived from Cultured Human Corneal Endothelium. IOVS 46: 3637-3644 [Abstract] [Full Text]
Tepavcevic, V, Blakemore, W.F (2005). Glial grafting for demyelinating disease. Phil Trans R Soc B 360: 1775-1795 [Abstract] [Full Text]
Nakamura, T., Terajewicz, A., Stein-Streilein, J. (2005). Mechanisms of Peripheral Tolerance following Intracameral Inoculation Are Independent of IL-13 or STAT6. J. Immunol. 175: 2643-2646 [Abstract] [Full Text]
Gregory, M. S., Koh, S., Huang, E., Saff, R. R., Marshak-Rothstein, A., Mukai, S., Ksander, B. R. (2005). A Novel Treatment for Ocular Tumors Using Membrane FasL Vesicles to Activate Innate Immunity and Terminate Immune Privilege. IOVS 46: 2495-2502 [Abstract] [Full Text]
Williams, K A, Standfield, S D, Smith, J R, Coster, D J (2005). Corneal graft rejection occurs despite Fas ligand expression and apoptosis of infiltrating cells. Br J Ophthalmol 89: 632-638 [Abstract] [Full Text]
Mimura, T., Yamagami, S., Yokoo, S., Usui, T., Tanaka, K., Hattori, S., Irie, S., Miyata, K., Araie, M., Amano, S. (2004). Cultured Human Corneal Endothelial Cell Transplantation with a Collagen Sheet in a Rabbit Model. IOVS 45: 2992-2997 [Abstract] [Full Text]
Kezuka, T., Takeuchi, M., Keino, H., Usui, Y., Takeuchi, A., Yamakawa, N., Usui, M. (2004). Peritoneal Exudate Cells Treated with Calcitonin Gene-Related Peptide Suppress Murine Experimental Autoimmune Uveoretinitis via IL-10. J. Immunol. 173: 1454-1462 [Abstract] [Full Text]
Camelo, S., Shanley, A., Voon, A. S. P., McMenamin, P. G. (2004). The Distribution of Antigen in Lymphoid Tissues following Its Injection into the Anterior Chamber of the Rat Eye. J. Immunol. 172: 5388-5395 [Abstract] [Full Text]
Boonman, Z. F. H. M., van Mierlo, G. J. D., Fransen, M. F., Franken, K. L. M. C., Offringa, R., Melief, C. J. M., Jager, M. J., Toes, R. E. M. (2004). Intraocular Tumor Antigen Drains Specifically to Submandibular Lymph Nodes, Resulting in an Abortive Cytotoxic T Cell Reaction. J. Immunol. 172: 1567-1574 [Abstract] [Full Text]
Dick, A. D., Carter, D., Robertson, M., Broderick, C., Hughes, E., Forrester, J. V., Liversidge, J. (2003). Control of myeloid activity during retinal inflammation. J. Leukoc. Biol. 74: 161-166 [Abstract] [Full Text]
Streilein, J. W. (2003). Ocular immune privilege: the eye takes a dim but practical view of immunity and inflammation. J. Leukoc. Biol. 74: 179-185 [Abstract] [Full Text]
Nakamura, T., Sonoda, K.-H., Faunce, D. E., Gumperz, J., Yamamura, T., Miyake, S., Stein-Streilein, J. (2003). CD4+ NKT Cells, But Not Conventional CD4+ T Cells, Are Required to Generate Efferent CD8+ T Regulatory Cells Following Antigen Inoculation in an Immune-Privileged Site. J. Immunol. 171: 1266-1271 [Abstract] [Full Text]
Gregory, M. S., Repp, A. C., Holhbaum, A. M., Saff, R. R., Marshak-Rothstein, A., Ksander, B. R. (2002). Membrane Fas Ligand Activates Innate Immunity and Terminates Ocular Immune Privilege. J. Immunol. 169: 2727-2735 [Abstract] [Full Text]
Zhu, B., Luo, L., Chen, Y., Paty, D. W., Cynader, M. S. (2002). Intrathecal Fas Ligand Infusion Strengthens Immunoprivilege of Central Nervous System and Suppresses Experimental Autoimmune Encephalomyelitis. J. Immunol. 169: 1561-1569 [Abstract] [Full Text]
Callegan, M. C., Engelbert, M., Parke, D. W. II, Jett, B. D., Gilmore, M. S. (2002). Bacterial Endophthalmitis: Epidemiology, Therapeutics, and Bacterium-Host Interactions. Clin. Microbiol. Rev. 15: 111-124 [Abstract] [Full Text]
Schurmans, L. R. H. M., Diehl, L., den Boer, A. T., Sutmuller, R. P. M., Boonman, Z. F. H. M., Medema, J. P., van der Voort, E. I. H., Laman, J., Melief, C. J. M., Jager, M. J., Toes, R. E. M. (2001). Rejection of Intraocular Tumors by CD4+ T Cells Without Induction of Phthisis. J. Immunol. 167: 5832-5837 [Abstract] [Full Text]
Kezuka, T., Sakai, J.-i., Usui, N., Streilein, J. W., Usui, M. (2001). Evidence for Antigen-Specific Immune Deviation in Patients With Acute Retinal Necrosis. Arch Ophthalmol 119: 1044-1049 [Abstract] [Full Text]
Yamagami, S., Dana, M. R. (2001). The Critical Role of Lymph Nodes in Corneal Alloimmunization and Graft Rejection. IOVS 42: 1293-1298 [Abstract] [Full Text]
Wang, Y., Goldschneider, I., O’Rourke, J., Cone, R. E. (2001). Blood mononuclear cells induce regulatory NK T thymocytes in anterior chamber-associated immune deviation. J. Leukoc. Biol. 69: 741-746 [Abstract] [Full Text]
Sonoda, K.-H., Faunce, D. E., Taniguchi, M., Exley, M., Balk, S., Stein-Streilein, J. (2001). NK T Cell-Derived IL-10 Is Essential for the Differentiation of Antigen-Specific T Regulatory Cells in Systemic Tolerance. J. Immunol. 166: 42-50 [Abstract] [Full Text]
Wenkel, H., Streilein, J. W., Young, M. J. (2000). Systemic Immune Deviation in the Brain That Does Not Depend on the Integrity of the Blood-Brain Barrier. J. Immunol. 164: 5125-5131 [Abstract] [Full Text]
Sonoda, K.-H., Exley, M., Snapper, S., Balk, S. P., Stein-Streilein, J. (1999). Cd1-Reactive Natural Killer T Cells Are Required for Development of Systemic Tolerance through an Immune-Privileged Site. JEM 190: 1215-1226 [Abstract] [Full Text]
Bigger, J. E., Thomas, C. A. III, Atherton, S. S. (1998). NK Cell Modulation of Murine Cytomegalovirus Retinitis. J. Immunol. 160: 5826-5831 [Abstract] [Full Text]