The Journal of Experimental Medicine
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Journal of Experimental Medicine, Vol 153, 743-747, Copyright © 1981 by Rockefeller University Press

ARTICLES

Induction of delayed-type hypersensitivity to azobenzenearsonate by a monoclonal anti-idiotype antibody

WR Thomas, G Morahan, ID Walker and JF Miller

Azobenzenearsonate (ABA)-specific sensitivity was induced in A/J mice by injecting a monoclonal anti-idiotype reagent, 14A, directed against a determinant present on a minor subpopulation of immunoglobulin molecules within the anti-ABA antibodies of A/J mice. Sensitivity was transferrable by purified T cells and this was abrogated by treating the cells with 14A, rabbit anti-mouse immunoglobulin and complement, not by treatment with only the last two reagents. The transfer was restricted by the K-end of the major histocompatibility complex.
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