Dendritic cells induce T cell proliferation to synthetic antigens under Ir gene control

doi:10.1084/jem.152.6.1817

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Dendritic cells induce T cell proliferation to synthetic antigens under Ir gene control

GH Sunshine, DR Katz and M Feldmann

Dendritic cells prepared by a modification of the method of Steinman and Cohn are I-A+ and FcR-. They are extremely potent at activating not only allogeneic T cell proliferation but also antigen-specific syngeneic T cell proliferation. Dendritic cells from nonresponder strains are unable to present antigens to responder X nonresponder T cells, suggesting that they may be a site of Ir gene product expression.
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