Journal of Experimental Medicine, Vol 152, 405-418, Copyright © 1980 by Rockefeller University Press

ARTICLES

Role of self and foreign antigenic determinants in allogeneic and self- restricted cytotoxic T cell recognition

RB Levy, PE Gilheany and GM Shearer

Murine spleen cells were sensitized in vitro to H-2 disparate allogeneic spleen cells and assayed on syngeneic target cells conjugated with the trinitrophenyl (TNP)-self or the fluorescein isothiocyanate (FITC)-self haptens, or on syngeneic target cells expressing the male H-Y antigen (H-Y self). The results indicated that allo-induced cytotoxic T lymphocytes (CTL) contained effectors that lysed both hapten-self but not H-Y self targets. Furthermore, it was demonstrated that separate populations of those allogeneic CTL were responsible for the lysis of TNP-self and FITC-self targets. This study also showed that cytotoxic effectors generated against the H-Y antigen with lytic activity equal to or greater than that of an allogeneically induced CTL response were unable to lyse hapten-self targets. These findings provide the first evidence that H-2 alloantigens may be unique in their ability to induce effectors that lyse hapten-conjugated autologous targets. These observations are discussed with respect to the self and foreign antigenic determinants involved in allogeneic and self-restricted CTL models.
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This article has been cited by other articles:

• Freese, A., Zavazava, N. (2002). HLA-B7 beta -pleated sheet-derived synthetic peptides are immunodominant T-cell epitopes regulating alloresponses. Blood 99: 3286-3292 [Abstract] [Full Text]  

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