The Journal of Experimental Medicine
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Journal of Experimental Medicine, Vol 152, 350-360, Copyright © 1980 by Rockefeller University Press

ARTICLES

Mature bone marrow erythroid burst-forming units do not require T cells for induction of erythropoietin-dependent differentiation

JM Lipton, EL Reinherz, M Kudisch, PL Jackson, SF Schlossman and DG Nathan

Cell-cell interactions between mature T cells and peripheral blood null cells induce erythropoietin-stimulated differentiation of peripheral blood-derived erythroid progenitors. By the use of complement-fixing cytolytic murine hybridoma and antibody uniquely reactive with mature T lymphocytes, this dependence of immature peripheral blood erythroid burst-forming unit (BFU-E) differentiation upon mature T cells or a T cell conditioned medium is confirmed. By using the same antibody, it is demonstrated that the differentiation of mature bone marrow BFU-E does not require either mature T cells or lymphocyte mitogenic factor. These findings do not preclude the presence in the bone marrow of other cells, perhaps even immature T cells, that influence erythropoietin- dependent erythroid differentiation of mature marrow BFU-E.
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