Journal of Experimental Medicine, Vol 149, 279-283, Copyright © 1979 by Rockefeller University Press

ARTICLES

Prostaglandins are necessary for osteoclast-activating factor production by activated peripheral blood leukocytes

T Yoneda and GR Mundy

The production of osteoclast-activating factor (OAF) by normal human peripheral blood leukocytes stimulated by phytohemagglutinin was inhibited by a series of structurally unrelated inhibitors of prostaglandin synthetase. Inhibition of OAF production by these agents was reversed by adding prostaglandins of the E series back to the leukocyte suspension. These results indicate that prostaglandin synthesis is necessary for OAF production.
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