Journal of Experimental Medicine, Vol 149, 244-253, Copyright © 1979 by Rockefeller University Press
The role of subregions of the rat major histocompatibility complex in the rejection and passive enhancement of renal allografts
GG Gallico, GW Butcher and JC Howard
The laboratory recombinant haplotype H-1acl of the Norway rat has been used
in studies of the rejection and passive enhancement of kidney allografts.
While the full H-1a haplotype provoked acute rejection, neither of the
isolated subregions, H-1Aa and H-1Ba, did so. It was also found that
alloantisera raised against either the H-1Aa or the H- 1Ba antigens would
enhance the grafts. It is suggested that both MHC subregions contain a
histocompatibility locus (i) for kidney (as they do for skin) and that in
the genetic combinations studied only incompatibility for both provokes a
response sufficient for rejection. In other combinations, however, single
region incompatibilities may be sufficient.
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