The Journal of Experimental Medicine
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Journal of Experimental Medicine, Vol 149, 244-253, Copyright © 1979 by Rockefeller University Press

ARTICLES

The role of subregions of the rat major histocompatibility complex in the rejection and passive enhancement of renal allografts

GG Gallico, GW Butcher and JC Howard

The laboratory recombinant haplotype H-1acl of the Norway rat has been used in studies of the rejection and passive enhancement of kidney allografts. While the full H-1a haplotype provoked acute rejection, neither of the isolated subregions, H-1Aa and H-1Ba, did so. It was also found that alloantisera raised against either the H-1Aa or the H- 1Ba antigens would enhance the grafts. It is suggested that both MHC subregions contain a histocompatibility locus (i) for kidney (as they do for skin) and that in the genetic combinations studied only incompatibility for both provokes a response sufficient for rejection. In other combinations, however, single region incompatibilities may be sufficient.
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