The Journal of Experimental Medicine
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Journal of Experimental Medicine, Vol 148, 1592-1611, Copyright © 1978 by Rockefeller University Press

ARTICLES

Immunological dissection of human Ia molecules

R Tosi, N Tanigaki, D Centis, GB Ferrara and D Pressman

The immunochemical analysis of Daudi Ia molecules by a variety of alloantisera led to the recognition of at least three molecular species carrying different antigenic determinants: DRw6, DC-1, and DC-2. Genetic as well as structural evidence indicates that DRw6 and DC-1 molecules are controlled by separate, HLA-linked loci, rather than by alleles at the same locus. The alloantigenic determinants appear to be expressed on the small Ia subunit. DC-1 and DC-2 determinants discussed had not been defined by serological analysis at the population level, but were demonstrated to be present by immunochemical analysis at the molecular level.
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