Spontaneous murine lupus-like syndromes. Clinical and immunopathological manifestations in several strains

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Spontaneous murine lupus-like syndromes. Clinical and immunopathological manifestations in several strains

BS Andrews, RA Eisenberg, AN Theofilopoulos, S Izui, CB Wilson, PJ McConahey, ED Murphy, JB Roths and FJ Dixon

MRL/1 and BXSB male mice have a systemic lupus erythematosus (SLE)-like disease similar to but more acute than that occurring in NZB X W mice. The common elements of lymphoid hyperplasia, B-cell hyperactivity, autoantibodies, circulating immune complex (IC), complement consumption, IC glomerulonephritis with gp70 deposition, and thymic atrophy were found in all three kinds of SLE mice. On the basis of these common elements, SLE seen in these mice can be considered a single disease in the same sense that human SLE is one disease. The differences in the SLE expressed in the different mice are no greater than those found in an unselected series of humans with SLE. However, the significant quantitative and qualitative variations in abnormal immunologic expression suggest that different constellations of factors, genetic and/or pathophysiologic, may operate in the three murine strains and that each constellation is capable of leading, via its particular abnormal immunologic consequences, to the activation of common immunopathologic effector mechanisms that cause quite similar SLE-like syndromes. From an experimental point of view, the availability of several inbred murine strains of commonplace histocompatibility types that express an SLE-like syndrome makes possible innumerable manipulations which should help to elucidate the nature and cause(s) of this disorder.
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Miyakawa, H., Sato, K., Shinbori, T., Okamoto, T., Gushima, Y., Fujiki, M., Suga, M. (2002). Effects of inducible nitric oxide synthase and xanthine oxidase inhibitors on SEB-induced interstitial pneumonia in mice. Eur Respir J 19: 447-457 [Abstract] [Full Text]
Takeda, I, Rayno, K, Movafagh, F B, Wolfson-Reichlin, M, Reichlin, M (2001). Dual binding capabilities of anti-double-stranded DNA antibodies and anti-ribosomal phosphoprotein (P) antibodies. Lupus 10: 857-865 [Abstract]
Priatel, J. J., Utting, O., Teh, H.-S. (2001). TCR/Self-Antigen Interactions Drive Double-Negative T Cell Peripheral Expansion and Differentiation into Suppressor Cells. J. Immunol. 167: 6188-6194 [Abstract] [Full Text]
Nazareth, M, Fanti, P, Schwach, C, Poppenberg, K, Janis, K, Aronica, S M (2001). Altered Bax expression and decreased apoptosis in bone marrow cells of lupus-susceptible NZB/W mice. Lupus 10: 785-793 [Abstract]
Esfandiari, E., McInnes, I. B., Lindop, G., Huang, F.-P., Field, M., Komai-Koma, M., Wei, X.-q., Liew, F. Y. (2001). A Proinflammatory Role of IL-18 in the Development of Spontaneous Autoimmune Disease. J. Immunol. 167: 5338-5347 [Abstract] [Full Text]
Schoenecker, J. G., Johnson, R. K., Lesher, A. P., Day, J. D., Love, S. D., Hoffman, M. R., Ortel, T. L., Parker, W., Lawson, J. H. (2001). Exposure of Mice to Topical Bovine Thrombin Induces Systemic Autoimmunity. Am. J. Pathol. 159: 1957-1969 [Abstract] [Full Text]
Jodo, S., Xiao, S., Hohlbaum, A., Strehlow, D., Marshak-Rothstein, A., Ju, S.-T. (2001). Apoptosis-inducing Membrane Vesicles. A NOVEL AGENT WITH UNIQUE PROPERTIES. J. Biol. Chem. 276: 39938-39944 [Abstract] [Full Text]
Feeney, A. J., Lawson, B. R., Kono, D. H., Theofilopoulos, A. N. (2001). Terminal Deoxynucleotidyl Transferase Deficiency Decreases Autoimmune Disease in MRL-Faslpr Mice. J. Immunol. 167: 3486-3493 [Abstract] [Full Text]
Hahn, B H (2001). Lessons in lupus: the mighty mouse. Lupus 10: 589-593
Monneaux, F., Dumortier, H., Steiner, G., Briand, J.-P., Muller, S. (2001). Murine models of systemic lupus erythematosus: B and T cell responses to spliceosomal ribonucleoproteins in MRL/Faslpr and (NZB NZW)F1 lupus mice. Int Immunol 13: 1155-1163 [Abstract] [Full Text]
Chan, O. T. M., Paliwal, V., McNiff, J. M., Park, S.-H., Bendelac, A., Shlomchik, M. J. (2001). Deficiency in {beta}2-Microglobulin, But Not CD1, Accelerates Spontaneous Lupus Skin Disease While Inhibiting Nephritis in MRL-Faslpr Mice: An Example of Disease Regulation at the Organ Level. J. Immunol. 167: 2985-2990 [Abstract] [Full Text]
Haywood, M. E. K., Vyse, T. J., McDermott, A., Thompson, E. M., Ida, A., Walport, M. J., Izui, S., Morley, B. J. (2001). Autoantigen Glycoprotein 70 Expression Is Regulated by a Single Locus, Which Acts as a Checkpoint for Pathogenic Anti-Glycoprotein 70 Autoantibody Production and Hence for the Corresponding Development of Severe Nephritis, in Lupus-Prone BXSB Mice1. J. Immunol. 167: 1728-1733 [Abstract] [Full Text]
Harari, O. A., Marshall, D., McHale, J. F., Ahmed, S., Haskard, D. O. (2001). Limited endothelial E- and P-selectin expression in MRL/lpr lupus-prone mice. Rheumatology (Oxford) 40: 889-895 [Abstract] [Full Text]
Wang, X., Kumanogoh, A., Watanabe, C., Shi, W., Yoshida, K., Kikutani, H. (2001). Functional soluble CD100/Sema4D released from activated lymphocytes: possible role in normal and pathologic immune responses. Blood 97: 3498-3504 [Abstract] [Full Text]
Santulli-Marotto, S., Qian, Y., Ferguson, S., Clarke, S. H. (2001). Anti-Sm B Cell Differentiation in Ig Transgenic MRL/Mp-lpr/lpr Mice: Altered Differentiation and an Accelerated Response. J. Immunol. 166: 5292-5299 [Abstract] [Full Text]