Journal of Experimental Medicine, Vol 148, 878-889, Copyright © 1978 by Rockefeller University Press

ARTICLES

The cellular basis of allograft rejection in vivo. I. The cellular requirements for first-set rejection of heart grafts

BM Hall, S Dorsch and B Roser

The nature of the cells required for first-set graft rejection in vivo was examined by using an adoptive transfer system to restore heart- graft rejection in irradiated rats. Highly purified inocula of peripheral T lymphocytes were shown to quantitatively account for the restorative ability of adoptively transferred cells. These T cells were shown to be long-lived small lymphocytes which are not recently derived from the thymus during adult life. They belong to the pool of T cells which constantly recirculate from blood to lymph as shown by their rapid appearance in the lymph of iradiated syngeneic rats after intravenous injection. Neither B lymphocytes nor antibodies in the circulation or in the graft itself are required for first-set graft rejection.
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