Role of viral infectivity in the induction of influenza virus-specific cytotoxic T cells

doi:10.1084/jem.147.4.1236

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Role of viral infectivity in the induction of influenza virus-specific cytotoxic T cells

TJ Braciale and KL Yap

This report examines the requirement for infectious virus in the induction of influenza virus-specific cytotoxic T cells. Infectious influenza virus was found to be highly efficient at generating both primary and secondary cytotoxic T-cell response in vivo. Inactivated influenza virus however, failed to stimulate a detectable cytotoxic T- cell response in vivo even at immunizing doses 10(5)-10(6)-fold higher than the minimum stimulatory dose of infectious virus. Likewise inactivated virus failed to sensitize target cells for T cell-mediated lysis in vitro but could stimulate a specific cytotoxic response from primed cells in vitro. Possible requirements for the induction of virus- specific cytotoxic T-cell responses are discussed in light of these observations and those of other investigators.
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