Journal of Experimental Medicine, Vol 147, 1126-1141, Copyright © 1978 by Rockefeller University Press

ARTICLES

The effect of helper virus on Abelson virus-induced transformation of lymphoid cells

N Rosenberg and D Baltimore

Abelson murine leukemia virus (A-MuLV)-transformed fibroblast nonproducer cells were used to prepare A-MuLV stocks containing a number of different helper viruses. The oncogenicity of the A-MuLV stocks was tested by animal inoculation and their ability to transform normal mouse bone marrow cells was measured in vitro. All of the A-MuLV stocks transformed fibroblast cells efficiently. However, only A-MuLV stocks prepared with helper viruses that are highly oncogenic were efficient in vivo and in vitro in hematopoietic cell transformation. In addition, inefficient helpers did not establish a stable infection in lymphoid nonproducer cells. Thus, helper virus has a more central role in lymphoid cell transformation than in fibroblast cell transformation.
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This article has been cited by other articles:

• Reuther, J. Y., Reuther, G. W., Cortez, D., Pendergast, A. M., Baldwin Jr., A. S. (1998). A requirement for NF-kappa B activation in Bcr-Abl-mediated transformation. Genes Dev. 12: 968-981 [Abstract] [Full Text]  
• Risser, R., Grunwald, D., Sinaiko, C., Jelen, P. (1980). Cell-surface Antigens of Abelson and Friend Murine Leukemia Viruses and of Hematopoietic Differentiation. Cold Spring Harb Symp Quant Biol 44: 1195-1204 [Abstract]  

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